代谢紊乱参与心房颤动机制的研究进展  

Mechanism of Metabolic Disorders Involved in Atrial Fibrillation

作　　者：赵云飞 杨东辉 ZHAO Yunfei;YANG Donghui(Department of Cardiology,The Second Hospital of Dalian Medical University,Dalian 116027,Liaoning,China)

机构地区：[1]大连医科大学附属第二医院心内科,辽宁大连116027

出　　处：《心血管病学进展》2021年第12期1085-1088,共4页Advances in Cardiovascular Diseases

摘　　要：目前心房颤动(房颤)具体病理生理机制尚不清楚,缺乏诊断房颤及预测其预后的循环标志物。最近,由于代谢组学研究方法的应用,越来越多证据表明房颤是一种高代谢状态,意味着代谢改变在房颤的病理生理学中可能具有重要作用。房颤的特点是心房肌不规则高频兴奋和收缩,它能影响心房能量需求、循环及供氧,从而改变代谢供需平衡,导致代谢应激。因此,探究房颤患者的代谢改变可以进一步了解房颤发生机制并为临床治疗方案提供更多的参考。At present,the specific pathophysiological mechanism of atrial fibrillation(Af)is not clear,and there has been a lack of circulatory markers for diagnosing Af and predicting its prognosis.Recently,due to the application of metabonomics research methods,more and more evidence shows that Af is a high metabolic state,which means that metabolic changes may play an important role in the pathophysiology.Af is characterized by irregular high-frequency excitation and contraction of atrial muscle.It can affect atrial energy demand,circulation and oxygen supply,thus changing the balance of metabolic supply and demand and leading to metabolic stress.Therefore,exploring the metabolic changes of patients with Af can further understand the mechanism of atrial fibrillation and provide more reference for clinical treatment.

关 键 词：心房颤动 代谢紊乱 核苷一磷酸活化蛋白激酶 氨基酸 脂肪酸 

分 类 号：R54[医药卫生—心血管疾病]