盐酸多奈哌齐联合舍曲林对急性脑梗死患者负性情绪的影响及血清HSP70、和肽素、S100B水平变化分析  

Influence of donepezil hydrochloride combined with sertraline on negative emotions in patients with acute cerebral infarction and the changes of serum levels of HSP70,Copeptin and S100B

作　　者：环晶晶 陈娟[1] 苏敏[1] HUAN Jing-jing;CHEN Juan;SU Min(Department of Emergency,Rugao Hospital Affiliated to Nantong University,Rugao People's Hospital,Rugao Jiangsu 226500,China)

机构地区：[1]南通大学附属如皋医院(如皋市人民医院)急诊科,江苏如皋226500

出　　处：《临床和实验医学杂志》2021年第23期2500-2504,共5页Journal of Clinical and Experimental Medicine

基　　金：江苏省医院协会医院管理创新研究课题(编号:2019-377)。

摘　　要：目的探究盐酸多奈哌齐联合舍曲林对急性脑梗死患者负性情绪的影响及血清热休克蛋白70(HSP70)、和肽素、S100B水平变化。方法回顾性分析2018年4月至2020年6月南通大学附属如皋医院收治的急性脑梗死患者97例,根据治疗方法不同分为观察组(n=48)和对照组(n=49),对照组采用盐酸多奈哌齐治疗,观察组在对照组基础上加用舍曲林治疗,治疗3个月。观察两组临床疗效,治疗3个月后负性情绪、血清指标(HSP70、和肽素、S100B)、认知功能及不良反应。结果观察组总有效率(91.67%)高于对照组(73.47%),差异有统计学意义(P<0.05)。治疗3个月后,观察组汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分为(10.31±3.42)、(12.84±1.88)分,低于对照组[(15.17±3.62)、(14.66±2.37)分],差异均有统计学意义(P<0.05)。观察组HSP70水平为(2.89±0.66)pg/m L,高于对照组[(2.65±0.53)pg/m L],和肽素、S100B水平为(1.87±0.54)pmol/L、(0.17±0.06)ng/m L,均低于对照组[(3.10±0.73)pmol/L、(0.21±0.07)ng/m L],差异均有统计学意义(P<0.05)。观察组神经功能缺损评分量表(NIHSS)评分为(5.49±1.37)分,低于对照组[(9.36±1.12)分],蒙特利尔认知评估量表(MoCA)评分为(29.16±2.26)分,高于对照组[(27.22±1.77)分],差异均有统计学意义(P<0.05)。观察组不良反应发生率(12.50%)高于对照组(8.16%),但两组比较差异无统计学意义(P>0.05)。结论急性脑梗死患者应用盐酸多奈哌齐联合舍曲林疗效显著,能够改善负性情绪及认知功能,提高血清HSP70水平,降低血清和肽素、S100B水平,且未新增不良反应。Objective To investigate the influence of donepezil hydrochloride combined with sertraline on negative emotions in patients with acute cerebral infarction and the changes of serum HSP70,Copeptin and S100 B levels.Methods Ninety-seven patients with acute cerebral infarction treated in the Rugao Hospital Affiliated to Nantong University from April 2018 to June 2020 were retrospectively analyzed and divided into an observation group(n=48)and a control group(n=49),and the control group was treated with donepezil hydrochloride.The observation group was treated with sertraline on the basis of the control group for 3 months.The clinical efficacy of the two groups was observed.The negative emotion,serum index(HSP70,Copeptin,S100 B),cognitive function and adverse reactions were observed before and 3 months after treatment.Results The total effective rate of the observation group(91.67%)was higher than that of the control group(73.47%),the difference was statistically significant(P<0.05).Three months after treatment,the scores of Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)in the observation group were(10.31±3.42),(12.84±1.88)points,which were lower than those in the control group[(15.17±3.62),(14.66±2.37)points],the differences were statistically significant(P<0.05).The level of HSP70 in observation group was(2.89±0.66)pg/m L,which were higher than those in control group[(2.65±0.53)pg/m L],while the levels of Copeptin and S100 B were(1.87±0.54)pmol/L,(0.17±0.06)ng/m L,which were lower than those in control group[(3.10±0.73)pmol/L,(0.21±0.07)ng/m L],the differences were statistically significant(P<0.05).The score of NIHSS in observation group were(5.49±1.37)points,which were lower than those in the control group[(9.36±1.12)points],and the scores of MOCA were(29.16±2.26)points,which were higher than those in control group[(27.22±1.77)points],the differences were statistically significant(P<0.05).The incidence of adverse reactions in observation group(12.50%)was higher than that in the contro

关 键 词：急性脑梗死 盐酸多奈哌齐 舍曲林 负性情绪 HSP70 和肽素 S100B 

分 类 号：R743.33[医药卫生—神经病学与精神病学]