抗NMDAR脑炎合并抗MOG炎性脱髓鞘疾病的研究进展  

Advances in anti-NMDAR encephalitis combined with anti-MOG inflammatory demyelinating disease

作　　者：刘雅微 韩婉君 吕亚楠 喻志敏 潘頔 李瑾[1] 杨丹(指导)[1] LIU Ya-Wei;HAN Wan-Jun;LYU Ya-Nan;YU Zhi-Min;PAN Di;LI Jin;YANG Dan(Department of Neurology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院神经内科,哈尔滨150081

出　　处：《中国免疫学杂志》2021年第24期3062-3064,共3页Chinese Journal of Immunology

基　　金：国家自然科学基金青年基金(81400982);黑龙江省自然科学基金青年基金(QC2018096);62批中国博士后科学基金(2017M621302);2017年度黑龙江省博士后资助(LBH-Z17220)项目。

摘　　要：抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎是一种中枢神经系统自身免疫性疾病,通常表现为复杂的神经精神综合征。抗髓鞘少突胶质细胞糖蛋白(myelin oligodendrocyte glycoprotein,MOG)的抗体与急性播散性脑脊髓炎(ADEM)、视神经炎(ON)和横贯性脊髓炎(TM)等疾病相关。抗NMDAR抗体和抗MOG抗体在罕见病例中共存。然而,抗NMDAR脑炎和抗MOG抗体炎性脱髓鞘疾病可同时或相继发生。因此,临床上应考虑这两种疾病同时发生的可能性,本文对抗NMDAR脑炎合并抗MOG炎性脱髓鞘疾病的临床特征、实验室检测、临床诊断及治疗的相关进展进行综述。Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis is an autoimmune disease of the central nervous system,usually manifested as a complex neuropsychiatric syndrome.Antibodies against myelin oligodendrocyte glycoprotein(MOG)are associated with acute disseminated encephalomyelitis(ADEM),optic neuritis(ON)and transverse myelitis(TM).Anti-NMDAR antibodies and anti-MOG antibodies coexist in rare cases.However,anti-NMDAR encephalitis and anti-MOG antibody inflammatory demyelinating diseases can occur simultaneously or sequentially.Therefore,the possibility of co-occurrence with these two diseases should be considered clinically.This article reviews the clinical features,laboratory testing,clinical diagnosis and treatment of anti-NMDAR encephalitis combined with anti-MOG inflammatory demyelinating disease.

关 键 词：抗NMDAR脑炎 抗髓鞘少突胶质细胞糖蛋白(MOG)抗体 脱髓鞘疾病 

分 类 号：R742.9[医药卫生—神经病学与精神病学] R744.5[医药卫生—临床医学]