β-淀粉样蛋白诱导依赖caspase-1/GSDMD通路的细胞焦亡与阿尔兹海默病的研究进展  

Research progress of caspase-1/GSDMD pathway-dependent pyroptosis induced byβ-amyloid and Alzheimer's disease

作　　者：李明希 张桂美 尚天玲 王咏纯 王梓铖 孙莉(指导)[1] LI Ming-Xi;ZHANG Gui-Mei;SHANG Tian-Ling;WANG Yong-Chun;WANG Zi-Cheng;SUN Li(Department of Neurology,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院神经内科,长春130021

出　　处：《中国免疫学杂志》2021年第24期3070-3072,F0003,F0004,共5页Chinese Journal of Immunology

摘　　要：阿尔兹海默病(AD)是一种最常见的神经退行性疾病,其特点是认知功能受损,以记忆力下降为主,严重影响老年人的日常生活能力。细胞焦亡作为一种新发现的炎症相关的细胞死亡方式,被证实参与AD发生发展过程。本文旨在总结细胞焦亡在AD中的可能致病机制,以期为AD防治提供新思路。Alzheimer's disease(AD)is one of the most common neurodegenerative diseases,characterized by impaired cognitive function,mainly in form of memory loss,which severely affects daily life of elderly.Pyroptosis is a newly identified mode of cell death associated with inflammation.A growing body of evidence has confirmed that pyroptosis is involved in pathological mechanisms of AD and influences progression of AD.This review summarizes possible pathogenic mechanisms of Aβ-induced pyroptosis in AD and aims to provide new insights for prevention and treatment of AD.

关 键 词：阿尔兹海默病 细胞焦亡 Β-淀粉样蛋白 炎症小体 

分 类 号：R741.02[医药卫生—神经病学与精神病学]