血清同型半胱氨酸、叶酸及维生素B_(12)与吸毒者血管硬化的相关性研究  

Correlation between serum homocysteine,folic acid and vitamin B_(12) and vascular sclerosis of drug addicts

作　　者：符明昌[1] 周莲[1] 郑志昂[1] 武翔佳 郑泽强 黎祥丽 FU Ming-chang;ZHOU Lian;ZHENG Zhi-ang;WU Xiang-jia;ZHENG Ze-qiang;LI Xiang-li(Department of Clinical Laboratory,Hainan Third People′s Hospital,Sanya 572000,China)

机构地区：[1]海南省第三人民医院检验科,海南三亚572000

出　　处：《实用药物与临床》2021年第12期1095-1098,共4页Practical Pharmacy and Clinical Remedies

基　　金：2019年度海南省卫生健康行业科研项目(1901-032024A2005)。

摘　　要：目的研究血清同型半胱氨酸、叶酸及维生素B_(12)与吸毒者血管硬化的相关性。方法将2019年1-12月初入戒毒所的98名男性吸毒者作为试验组,并根据是否发生血管硬化分为血管硬化组(56例)及血管非硬化组(42例)。选取同时期做体验的98例男性健康者作为对照组,采用化学发光免疫分析法检测试验组和对照组被检者的血清同型半胱氨酸(Hcy),同时测定其血清叶酸及维生素B_(12)水平,通过Pearson相关分析指标的相关性。结果血管硬化组的血清叶酸、维生素B_(12)水平均显著低于非硬化组和对照组(P<0.05),血管硬化组的血清Hcy水平显著高于非硬化组和对照组(P<0.05);Pearson相关性分析显示,血管硬化组中血清Hcy与叶酸呈明显负相关(r=-0.43,P<0.05),血清Hcy与维生素B_(12)呈明显负相关(r=-0.47,P<0.05);血管硬化组的高半胱氨酸血症(HHcy)的发生率明显高于非硬化组和对照组(P<0.05),在高于血清Hcy参考值上限的不同水平(>50μmol/L、31~50μmol/L、16~30μmol/L)上,三组分布不同,与对照组和非硬化组相比,血管硬化组在大于血清Hcy参考值上限的不同水平分布居多,差异有统计学意义(P<0.05)。结论已有血管硬化的吸毒者的血清叶酸及维生素B_(12)水平降低,同型半胱氨酸水平升高。对于戒毒所内发生血管硬化的吸毒者可以通过补充叶酸和维生素B_(12)来降低同型半胱氨酸水平,以预防血栓形成。Objective To study the correlation between serum homocysteine,folic acid and vitamin B_(12)and vascular sclerosis of drug addicts.Methods Totally 98 male drug addicts who entered drug rehabilitation center from January 2019 to December 2019 were divided into vascular sclerosis group(n=56)and vascular non-sclerosis group(n=42)according to whether vascular sclerosis occurred.All the cases were obtained from Sanya Disease Prevention and Control Center.A total of 98 male healthy people who underwent physical examination during the same period of time were selected as the control group.The serum homocysteine(Hcy),folic acid and vitamin B in the test group and the control group were detected by chemiluminescence immunoassay.The correlation among the indexes was analyzed by Pearson analysis.Results The serum folic acid and vitamin B_(12)levels in sclerosis group were significantly lower than those in non-sclerosis group and control group(P<0.05),while the serum Hcy levels in sclerosis group were significantly higher than those in non-sclerosis group and control group(P<0.05).Pearson correlation analysis showed that serum Hcy was negatively correlated with folic acid(r=-0.43,P<0.05)and vitamin B_(12)(r=-0.47,P<0.05)in arteriosclerosis group.The incidence of HHcy in sclerosis group was significantly higher than that in non-sclerosis group and control group(P<0.05).The distribution of HHcy in three groups was different at different levels(>50μmol/L,31~50μmol/L,16~30μmol/L).Compared with control group and non-sclerosis group,the distribution of HHcy in sclerosis group was much higher at different levels of Hcy which was higher than the upper limit of reference value(P<0.05).Conclusion Serum folic acid and vitamin B_(12)levels of drug addicts with arteriosclerosis are decreased,while homocysteine levels are increased.For drug addicts with arteriosclerosis in drug rehabilitation centers,proper folic acid and vitamin B_(12)can be supplemented to reduce homocysteine levels to prevent thrombosis.

关 键 词：吸毒者 血管硬化 叶酸 同型半胱氨酸 维生素B_(12) 

分 类 号：R749.64[医药卫生—神经病学与精神病学]