丁苯酞氯化钠注射液对不同TOAST分型急性期脑梗死疗效的比较  

Comparison of the therapeutic effects of butylphthalide sodium chloride injection on different TOAST types of acute cerebral infarction

作　　者：许娟娟[1] 刘东亮 骆嵩[1] 屈洪党[1] XU Juan-juan;LIU Dong-liang;LUO Song;QU Hong-dang(Department of Neurology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院神经内科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2021年第12期1711-1714,共4页Journal of Bengbu Medical College

基　　金：安徽省高校自然科学研究重点项目(KJ2019A0364);蚌埠医学院自然科学重点项目(BYKY20190612D)。

摘　　要：目的:探讨丁苯酞氯化钠注射液对TOAST分型中不同亚型的急性期脑梗死病人的疗效。方法:选取180例急性期脑梗死病人为研究对象,按照随机化原则分为对照组和观察组,所有入组的病例均按照TOAST分型标准进行分型。其中对照组60例,采用内科常规治疗,观察组120例在对照组的的常规脑梗死治疗基础上加用丁苯酞氯化钠注射液。记录2组病人治疗前及治疗后2周的NIHSS评分、ADL评分,对2组病人的总有效率以及组间相同亚型的疗效进行对比分析。结果:观察组治疗2周后,NIHSS评分(5.50±3.44)分较对照组(8.02±3.39)分明显降低,ADL评分(61.83±9.79)分较对照组(56.42±10.21)分显著升高,差异有统计学意义(P<0.01);观察组治疗2周后总有效率(88.3%)较对照组(78.3%)高,且观察组LAA分型病人治疗后总有效率高于CE及SAO型病人,差异均有统计学意义(P<0.05~P<0.01)。结论:丁苯酞氯化钠注射液对急性期脑梗死病人具有较好的疗效,能显著改善脑梗死病人的神经功能缺损症状及生活自理能力,对于TOAST分型中的LAA型病人具有更好的疗效。Objective:To investigate the effects of butylphthalide sodium chloride injection on different subtypes of patients with acute cerebral infarction(ACI)in TOAST classification.Methods:One hundred and eighty patients with ACI were classified according to the TOAST classification standard,and divided randomly into the control group(60 cases)and observation group(120 cases).The control group was treated with the routine medical treatment,and the observation group was additionally treated with butylphthalide sodium chloride injection on the basis of the routine treatment.The NIHSS score and ADL score in the two groups before treatment and after 2 weeks of treatment were recorded,and the total effective rate and efficacy of the same subtype were compared between the two groups.Results:After 2 weeks of treatment,the NIHSS score in observation group(5.50±3.44)points was significantly lower than that in control group(8.02±3.39)points,and the score of ADL in observation group(61.83±9.79)points was significantly higher than that in control group(56.42±10.21)points(P<0.01).After 2 weeks of treatment,the total effective rate in observation group(88.3%)was higher than that in control group(78.4%),and the overall response rate of type LAA patients was higher than that of type CE and SAO patients in observation group(P<0.05 to P<0.01).Conclusions:Butylphthalide sodium chloride injection has good effects on patients with ACI,which can significantly improve the symptoms of neurological impairment and self-care ability of patients,and has better effects on LAA patients in TOAST classification.

关 键 词：脑梗死 丁苯酞氯化钠注射液 TOAST分型 

分 类 号：R743.3[医药卫生—神经病学与精神病学]