2018—2019年南昌市社区肺癌高危人群筛查结果及危险因素分析  

Analysis of screening results and risk factors of high-risk populations of lung cancer in Nanchang city from 2018 to 2019

作　　者：任剑[1] 王晓波 舒虹 熊婉菁 魏清风[1] 汪鑫[2] 石楠 熊小玲[1] Ren Jian;Wang Xiaobo;Shu Hong;Xiong Wanjing;Wei Qingfeng;Wang Xin;Shi Nan;Xiong Xiaoling(Jiangxi Cancer Centre,Jiangxi Tumor Hospital,Nanchang 330029,China;Preventive Medicine Teaching and Research Section,School of Basic Medicine,Jiujiang University,Jiujiang 332000,China;Jiangxi Medical College,Shangrao 334000,China)

机构地区：[1]江西省癌症中心,江西省肿瘤医院癌症中心办公室,南昌330029 [2]九江学院基础医学院预防医学教研室,332000 [3]江西省医学高等专科学校护理学院,上饶334000

出　　处：《中华肿瘤杂志》2021年第12期1316-1321,共6页Chinese Journal of Oncology

基　　金：国家自然科学基金(81360447);江西省卫健委科技计划(20203568)。

摘　　要：目的分析2018—2019年南昌市社区肺癌高危人群筛查结果,探讨肺阳性结节和肺癌的危险因素。方法收集2018年11月至2019年10月江西省南昌市8个行政区、15个街道卫生服务中心的所有筛查对象的资料,评估肺癌高风险人群,对肺癌高风险人群进行低剂量螺旋CT临床筛查,分析疑似肺癌和肺阳性结节患者的危险因素。结果评估参加筛查的25871例人群中,肺癌高危人群为5220例,无其他恶性肿瘤高危风险人数为15374例。参加临床低剂量螺旋CT筛查2417例,其中肺阳性结节193例,疑似肺癌67例,其他肺部疾病912例,肺癌或肺阳性结节的阳性率为10.76%(260/2417)。单因素分析显示,年龄、粗粮摄入、油脂摄入、住房取暖、被动吸烟、饮酒和精神创伤与肺结节阳性或肺癌的发生有关(均P<0.05)。多因素分析显示,性别、年龄、住房取暖、吸烟和饮酒与肺结节或肺癌的发生有关(均P<0.05)。结论男性较女性患肺癌或肺阳性结节风险更高,年龄是肺阳性结节或肺癌独立危险因素,在一定范围内,年龄增长会增加肺癌的发病率,住房取暖可能是肺癌发病的保护因素,吸烟、饮酒是肺癌发病的危险因素。Objective To collate and analyze the screening results of high-risk lung cancer populations in communities in Nanchang from 2018 to 2019,and to explore the lung-positive nodules and risk factors for lung cancer.Methods Data of the screening subjects in 8 administrative districts and 15 street health service centers in Nanchang city,Jiangxi province from November 2018 to October 2019 were collected,people at high risk of lung cancer was assessed,clinical screening of high-risk groups of lung cancer was conducted by low-dose helical computed tomography(LDCT),and risk factors for suspected lung cancer and lung-positive nodules were analyzed.Results Of the 25871 people participated in screening,5220 were at high risk for lung cancer and 15374 without other malignant tumors were at high risk.There were 2417 cases participated in clinical LDCT screening,including 193 cases of lung-positive nodules,67 cases of suspected lung cancer,912 cases of other lung diseases,the positive rate of lung cancer or lung-positive nodules was 10.76%(260/2417).Univariate analysis showed that age,coarse grain intake,oil intake,housing heating,passive smoking,alcohol consumption and mental trauma were associated with positive pulmonary nodules or lung cancer(all P<0.05).Multivariate analysis showed that gender,age,housing heating,smoking and drinking were related to the occurrence of lung nodules or lung cancer(all P<0.05).Conclusions Men are more likely to develop lung cancer or lung-positive nodules than women.The age is an independent risk factor for lung-positive nodules or lung cancer.In a certain range,age will increase the incidence of lung cancer,housing heating may be the protective factor for lung cancer,while smoking and drinking are risk factors.

关 键 词：肺肿瘤 肺结节 高危人群 早期筛查 危险因素 

分 类 号：R734.2[医药卫生—肿瘤]