血清NSE、PCT及钙离子检测在热性惊厥与癫痫患儿疾病评估中的应用研究  

Application of serum NSE,PCT and calcium in the evaluation of febrile convulsion and epilepsy in children

作　　者：洪丽 陈蓉蓉 王晓康 张凡[1] 周金君[1] 陆艺 康爱建[1] 张小华[1] 李双双[1] HONG Li;CHEN Rong-rong;WANG Xiao-kang;ZHANG Fan;ZHOU Jin-jun;LU Yi;KANG Ai-jian;ZHANG Xiao-hua;LI Shuang-shuang(Department of Pediatrics,Maternal and Child Health Hospital Affiliated to Nantong University,Nantong 226018,China)

机构地区：[1]南通大学附属妇幼保健院儿科,江苏南通226018 [2]南通大学附属妇幼保健院外科,江苏南通226018

出　　处：《武警后勤学院学报（医学版）》2021年第12期114-116,共3页Journal of Logistics University of PAP（Medical Sciences）

基　　金：南通市卫生和计划生育委员会科研课题(No.MA2019012)。

摘　　要：【目的】分析在热性惊厥与癫痫患儿疾病评估中应用血清神经元特异性烯醇化酶(neuron-specific enolase,NSE)、血清降钙素原(procalcitonin,PCT)及钙离子检测的临床价值。【方法】抽取我院2018年1月至2021年3月收治的20例癫痫患儿和20例热性惊厥患儿作为研究对象,同时在同一时间段内从我院选取非感染和非神经源性疾病其他疾病患儿20例作为对照组,对三组所选研究对象均进行血清NSE、PCT及钙离子检测,比较不同惊厥程度血清NSE、PCT及钙离子水平。【结果】血清NSE水平在癫痫患儿和热性惊厥患儿病情发作24 h之内显著高于对照组(P<0.05)。血清钙离子水平在癫痫患儿和热性惊厥患儿病情发作24 h之内显著低于对照组(P<0.05)。血清PCT在癫痫患儿和热性惊厥患儿病情发作24 h之内与对照组无差异(P>0.05)。严重惊厥患儿血清NSE水平高于较轻惊厥患儿,血清钙离子水平低于较轻惊厥患儿(P<0.05)。不同惊厥程度患儿的血清PCT无差异(P>0.05)。【结论】无论是热性惊厥还是癫痫均可能导致血清NSE水平升高,同时会导致血清钙离子水平降低;热性惊厥严重程度与血清NSE水平和血清钙离子水平存在紧密联系,而血清PCT水平和惊厥的发生不存在明显联系。【Objective】To analyze the clinical value of serum neuron specific enolase(NSE),serum procalcitonin(PCT)and calcium in the evaluation of febrile convulsion and epilepsy in children.【Methods】20 children with epilepsy and 20 children with febrile convulsion treated in our hospital from January 2018 to March 2021 were selected as the research objects.At the same time,20 children with non infectious and non-neurogenic diseases and other diseases were selected from our hospital as the control group.The serum NSE,PCT and calcium of the three groups were detected,and the serum NSE,PCT and calcium of different degrees of convulsion were compared PCT and calcium levels.【Results】The level of serum NSE in children with epilepsy and febrile convulsion was significantly higher than that in the control group within 24 hours(P<0.05).The level of serum calcium in children with epilepsy and febrile convulsion was significantly lower than that in the control group within 24 hours(P<0.05).There was no difference in serum PCT between children with epilepsy and children with febrile convulsion within 24 hours of onset and the control group(P>0.05).The level of serum NSE in children with severe convulsion was higher than that in children with mild convulsion,and the level of serum calcium was lower than that in children with mild convulsion(P<0.05).There was no difference in serum PCT among children with different degrees of convulsion(P>0.05).【Conclusion】Both febrile convulsion and epilepsy may lead to the increase of serum NSE level and the decrease of serum calcium level.At the same time,the severity of febrile convulsion is closely related to serum NSE level and serum calcium level,but there is no significant relationship between serum PCT level and the occurrence of convulsion.

关 键 词：热性惊厥 癫痫 钙离子 降钙素原 神经元特异性烯醇化酶 

分 类 号：R748[医药卫生—神经病学与精神病学]