Precise Modulation Strategies for Transcranial Magnetic Stimulation:Advances and Future Directions  

作　　者：Gangliang Zhong Zhengyi Yang Tianzi Jiang 

机构地区：[1]Brainnetome Center,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China [2]National Laboratory of Pattern Recognition,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China [3]CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China [4]Key Laboratory for NeuroInformation of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,China

出　　处：《Neuroscience Bulletin》2021年第12期1718-1734,共17页神经科学通报（英文版）

基　　金：the Chinese Academy of Sciences,Science and Technology Service Network Initiative(KFJ-STS-ZDTP-078);the National Natural Science Foun-dation of China(31620103905);the Science Frontier Program of the Chinese Academy of Sciences(QYZDJ SSW-SMC019);the National Key R&D Program of China(2017YFA0105203)。

摘　　要：Transcranial magnetic stimulation(TMS)is a popular modulatory technique for the noninvasive diagnosis and therapy of neurological and psychiatric diseases.Unfortunately,current modulation strategies are only modestly effective.The literature provides strong evidence that the modulatory effects of TMS vary depending on device components and stimulation protocols.These differential effects are important when designing precise modulatory strategies for clinical or research applications.Developments in TMS have been accompanied by advances in combining TMS with neuroimaging techniques,including electroencephalography,functional nearinfrared spectroscopy,functional magnetic resonance imaging,and positron emission tomography.Such studies appear particularly promising as they may not only allow us to probe affected brain areas during TMS but also seem to predict underlying research directions that may enable us to precisely target and remodel impaired cortices or circuits.However,few precise modulation strategies are available,and the long-term safety and efficacy of these strategies need to be confirmed.Here,we review the literature on possible technologies for precise modulation to highlight progress along with limitations with the goal of suggesting future directions for this field.

关 键 词：Transcranial magnetic stimulation Modulation strategies Precise stimulation target Coil location Individual treatment paradigm 

分 类 号：R749[医药卫生—神经病学与精神病学]