辐照血对NSCLC手术患者免疫功能及预后的影响  

Effects of irradiated blood on immune function and prognosis of patients undergoing NSCLC surgery

作　　者：魏莉 周健 查小卉 WEI Li;ZHOU Jian;ZHA Xiao-hui(Department of Storage and Supply,Yangzhou Central Blood Station,Yangzhou 225000,Jiangsu,China;Department of Composition,Yangzhou Central Blood Station,Yangzhou 225000,Jiangsu,China)

机构地区：[1]扬州市中心血站储供科,江苏扬州225000 [2]扬州市中心血站成分科,江苏扬州225000

出　　处：《川北医学院学报》2021年第12期1609-1612,共4页Journal of North Sichuan Medical College

基　　金：江苏省输血协会英科新创科研基金项目(JS2018040)。

摘　　要：目的:探讨辐照血对非小细胞肺癌(NSCLC)手术患者免疫功能及预后的影响。方法:选取80例行手术治疗的NSCLC患者为研究对象,按照不同输血分为对照组和观察组,每组各40例。对照组患者在术中输注普通新鲜血,观察组患者在术中输注辐照血。比较两组患者免疫学及血清学指标、预后及不良反应发生情况。结果:术后7 d,观察组CD 4^(+)、CD 4^(+)/CD 8^(+)、CD 8^(+)水平与术前比较,差异无统计学意义(P>0.05);对照组CD 4^(+)、CD 4^(+)/CD 8^(+)水平低于术前和观察组(P<0.05),CD 8^(+)水平高于术前和观察组(P<0.05);观察组免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平与术前比较,差异无统计学意义(P>0.05);对照组IgG、IgA、IgM水平低于术前和观察组(P<0.05);观察组白细胞介素-6(IL-6)、IL-10、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)水平与术前比较,差异无统计学意义(P>0.05);对照组TNF-α、IFN-γ水平低于术前和观察组(P<0.05),IL-10、IL-6水平高于术前和观察组(P<0.05)。观察组1年及3年生存率高于对照组(P<0.05);观察组住ICU时间、住院时间短于于对照组(P<0.05)。观察组不良反应总发生率低于对照组(P<0.05)。结论:与输注普通血相比,输注辐照血不仅能满足NSCLC手术患者对血液的需求,且能避免异体血输注对机体免疫功能的抑制作用,有利于改善患者预后,并降低输血引起的不良反应发生率。Objective:To investigate the effects of irradiated blood on immune function and prognosis of patients with non-small cell lung cancer(NSCLC)undergoing surgery.Methods:80 NSCLC patients receiving surgical treatment were selected and divided into control group and observation group according to different blood transfusion methods,with 40 cases in each group.The control group received intraoperative transfusion of ordinary fresh blood,and the observation group received intraoperative transfusion of irradiated blood.Immunological and serological indexes,prognosis and the incidence of adverse reactions in two groups were compared.Results:On the 7th day after operation,the levels of CD 4^(+),CD 4^(+)/CD 8^(+)and CD 8^(+)in the observation group had no significant difference compared with those before operation(P>0.05),while the levels of CD 4^(+),CD 4^(+)/CD 8^(+)in the control group were significantly lower than those before operation and in the observation group(P<0.05),and the level of CD 8^(+)in the control group was significantly higher than that before operation and in the observation group(P<0.05).The levels of immunoglobulin A(IGA),immunoglobulin M(IgM)and immunoglobulin G(IgG)in the observation group had no significant difference compared with those before operation(P>0.05),while the levels of IgG,IgA and IgM in the control group were significantly lower than those before operation and in the observation group(P<0.05).The levels of interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ)in the observation group were not significantly different from those before surgery(P>0.05),and the levels of TNF-αand IFN-γin control group were significantly lower than those before operation and observation group(P<0.05),the levels of IL-10 and IL-6 in control group were significantly higher than those before operation and observation group(P<0.05).The 1-year and 3-year survival rates in the observation group were significantly higher than those in the control group(P<0.05).The du

关 键 词：非小细胞肺癌 手术 辐照血 免疫功能 预后 

分 类 号：R734[医药卫生—肿瘤]