生物基十二碳二元酸结晶热力学和动力学研究  

Study on the thermodynamics and kinetics of crystallization ofbio-based dodecanedioic acid

作　　者：陈李 段九龙 黄金[1] CHEN Li;DUAN Jiulong;HUANG Jin(College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]浙江工业大学药学院,浙江杭州310014

出　　处：《发酵科技通讯》2021年第4期218-222,共5页Bulletin of Fermentation Science and Technology

摘　　要：在生物基十二碳二元酸(DC_(12))产品精制工艺中,结晶单元的粗放性操作往往会造成产品晶体粉末化、易结块和纯度低等问题,开展DC_(12)结晶热力学和动力学研究可从理论上指导结晶过程以有效解决以上问题。笔者采用梅特勒-托利多在线结晶工作站和聚焦光束反射测量(FBRM)技术,进行了DC_(12)结晶热力学和动力学研究。结果表明:DC_(12)在乙酸301.15~334.15 K下的溶解度随着温度的升高呈显著增高趋势,采用λh和Apelblat方程对溶解度曲线进行拟合,发现Apelblet方程拟合度更好;介稳区宽度随着搅拌速率的增大和降温速率的降低而变窄,确定降温结晶搅拌速率为200 r/min,降温速率为0.3 K/min;建立了DC_(12)结晶生长动力学模型,该模型较好地拟合了降温结晶过程。In the refining process of DC_(12) products,the extensive operation of crystallization unit often causes many problems such as poor crystal size distribution(CSD),heavily agglomerated character,low purity and so on.The study of crystallization thermodynamics and kinetics of DC_(12) can theoretically guide the crystallization process and effectively solve the above problems.The crystallization thermodynamics and kinetics of DC_(12) were systematically studied by METTLER TOLEDO online crystallization workstation and focused beam reflection measurement(FBRM)technique.The results showed that the solubility of DC_(12) in acetic acid at 301.15~334.15 K increased significantly with the increase of temperature.Theλh and Apelblat equation were used to fit the solubility curve,and it was found that the Apelblet equation fit well.The metastable zone width(MSZW)narrowed with the increase of the stirring speed and the decrease of cooling rate.In the subsequent cooling crystallization operation processes,the stirring speed was determined at 200 r/min,and the cooling rate at about 0.3 K/min.The DC_(12) crystal growth kinetic equation was established,which fit the cooling crystallization process well.

关 键 词：十二碳二元酸 结晶 热力学 动力学 在线结晶工作站 

分 类 号：TQ225.1[化学工程—有机化工]