Effects of targeted muscle reinnervation on spinal cord motor neurons in rats following tibial nerve transection  

作　　者：Wei Lu Jian-Ping Li Zhen-Dong Jiang Lin Yang Xue-Zheng Liu 

机构地区：[1]Department of Human Anatomy,School of Basic Medical Scinences,Guangxi Medical University,Nanning,Guangxi Zhuang Autonomous Region,China [2]Department of Human Anatomy,Zhuhai Campus of Zunyi Medical University,Zhuhai,Guangdong Province,China

出　　处：《Neural Regeneration Research》2022年第8期1827-1832,共6页中国神经再生研究（英文版）

基　　金：funded by the National Natural Science Foundation of China,Nos.81760416,81960419,81927804(all to LY);Science and Technology foundation of Guizhou Province,No.[2017]1226(to LY);Support Plan for High Level Talents in Guizhou High Education Institutions,No.KY[2018]056(to LY).

摘　　要：Targeted muscle reinnervation(TMR)is a surgical procedure used to transfer residual peripheral nerves from amputated limbs to targeted muscles,which allows the target muscles to become sources of motor control information for function reconstruction.However,the effect of TMR on injured motor neurons is still unclear.In this study,we aimed to explore the effect of hind limb TMR surgery on injured motor neurons in the spinal cord of rats after tibial nerve transection.We found that the reduction in hind limb motor function and atrophy in mice caused by tibial nerve transection improved after TMR.TMR enhanced nerve regeneration by increasing the number of axons and myelin sheath thickness in the tibial nerve,increasing the number of anterior horn motor neurons,and increasing the number of choline acetyltransferase-positive cells and immunofluorescence intensity of synaptophysin in rat spinal cord.Our findings suggest that TMR may enable the reconnection of residual nerve fibers to target muscles,thus restoring hind limb motor function on the injured side.

关 键 词：function reconstruction motor neuron nerve injury nerve implant Nissl staining spinal cord SYNAPTOPHYSIN targeted muscle reinnervation tibial nerve TRANSECTION 

分 类 号：R651.3[医药卫生—外科学]