双相情感障碍并发代谢综合征的危险因素分析  

Risk factors of bipolar disorder complicated with metabolic syndrome

作　　者：陈长浩[1] 赵永华 朱肖飞 韩鹏飞[1] 沈子童[1] 祁雪艳 CHEN Chang-hao;ZHAO Yong-hua;ZHU Xiao-fei;HAN Peng-fei;SHEN Zi-tong;QI Xue-yan(Department of Psychiatry,Suzhou Second People s Hospital,Suzhou,Anhui 234000,China;不详)

机构地区：[1]安徽省宿州市第二人民医院精神科,安徽宿州234000 [2]安徽医科大学附属宿州医院中医科,安徽宿州234000

出　　处：《中国临床研究》2021年第12期1652-1654,共3页Chinese Journal of Clinical Research

基　　金：安徽省卫生健康委科研重点项目(AHWJ2021a044);宿州市科学技术重点攻关领域项目(2020117)。

摘　　要：目的探讨双相情感障碍并发代谢综合征的危险因素,为其临床预防及治疗提供参考。方法回顾性分析2019年12月至2021年3月在安徽省宿州市第二人民医院治疗的82例双相情感障碍患者的诊疗情况,依据是否并发代谢综合征分为综合征组与无综合征组,各41例。收集患者的年龄、性别、吸烟史、病程、高血压、糖尿病、抗精神病类药物使用种类等状况,并对患者的血压、血糖、血脂水平进行检测,使用Logistic回归分析双相情感障碍并发代谢综合征的危险因素。结果两组病程、年龄、性别、吸烟史、诊断分型、抗精神病药和心境稳定剂使用率相比,差异无统计学意义(P>0.05);无综合征组无糖尿病家族史发生率高于综合征组,用药种类少于综合征组,差异有统计学意义(P<0.01);多因素Logistic回归分析显示,有糖尿病家族史(OR=6.938,95%CI:1.227~39.238,P=0.028)、用药种类多(OR=3.016,95%CI:1.256~7.244,P=0.014)是双相情感障碍并发代谢综合征的危险因素。结论使用抗精神病类药物种类多、有糖尿病史是双相情感障碍并发代谢综合征的危险因素。Objective To explore the risk factors of bipolar disorder(BD) complicated with metabolic syndrome and provide references for the clinical prevention and treatment. Methods A retrospective analysis was conducted on 82 BD patients treated at Suzhou Second People’s Hospital from December 2019 to March 2021. According to whether the patients were complicated with metabolic syndrome, they were divided into syndrome group and no-syndrome group(n=41, each). The data of patients’ age, gender, smoking history, course of disease, hypertension, diabetes and the types of antipsychotic drugs were collected, and blood pressure, blood glucose and lipids levels were detected. Logistic regression was used to analyze the risk factors of BD complicated with metabolic syndrome. Results There was no significant difference in the course of disease, age, gender, smoking history, diagnostic classification of antipsychotic and mood stabilizers between two groups(P>0.05). The incidence of family history of diabetes and the types of medication in no syndrome group were significantly lower than those in syndrome group(P<0.01). Multivariate Logistic regression analysis showed that family history of diabetes(OR=6.938,95% CI:1.227-39.238, P=0.028) and more types of medications(OR=3.016, 95% CI:1.256-7.244, P=0.014) were the risk factors of bipolar disorder complicated with metabolic syndrome. Conclusion The use of more types of antipsychotics and the history of diabetes are risk factors for bipolar disorder complicated with metabolic syndrome.

关 键 词：双相情感障碍 代谢综合征 危险因素 糖尿病 抗精神病类药物 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R589[医药卫生—临床医学]