乳酸菌抑菌作用机制的研究进展  

Research Progress in Antibacterial Mechanism of Lactic Acid Bacteria

作　　者：胡爱心 刘金松 许英蕾 吴艳萍 HU Aixin;LIU Jinson;XU Yinglei;WU Yanping(College of Animal Science and Technology,College of Veterinary Medicine,Zhejiang Agricultural and Forestry University,Hangzhou 311300,China;Zhejiang Huijia Bio-Technology Co.,Ltd.,Huzhou 313300,China)

机构地区：[1]浙江农林大学动物科技学院·动物医学院,杭州311300 [2]浙江惠嘉生物科技股份有限公司,湖州313300

出　　处：《动物营养学报》2021年第12期6690-6698,共9页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：浙江省自然科学基金探索项目(LQ21C170001);浙江农林大学科研发展基金项目(2020FR003)。

摘　　要：乳酸菌作为重要的饲用益生菌已广泛应用于畜牧生产中,其具有提高动物生长性能、改善肠道环境、增强免疫力和维持动物健康等作用。乳酸菌发挥益生功能的重要机理之一是抑制肠道病原菌。本文从抑菌物质、竞争黏附位点、调控肠道菌群平衡及激活宿主免疫等方面总结了近年来有关乳酸菌抑菌分子机制的研究进展,以及对畜禽主要病原菌的抑制效果,以期为乳酸菌替代抗生素应用于防治病原菌感染提供参考依据。As an important probiotic for feeding,lactic acid bacteria have been widely used in animal husbandry,which can improve animal growth performance,improve intestinal environment,enhance immunity and maintain animal health.Inhibition of intestinal pathogens is one of the important mechanisms of lactic acid bacteria exerting probiotic function.In this paper,the research progress on the molecular mechanism of lactic acid bacteria in recent years was summarized from the aspects of antimicrobial substances,competitive adhesion sites,regulation of intestinal flora balance and activation of host immunity,as well as the inhibitory effect on main pathogenic bacteria of livestock and poultry,in order to provide a reference for the application of lactic acid bacteria as an alternative to antibiotics in the prevention and treatment of pathogenic bacteria infection.

关 键 词：乳酸菌 抑菌分子机制 肠道病原菌 畜禽健康 

分 类 号：S816[农业科学—饲料科学]