基于脑功能网络分析的孤独症儿童辅助干预效果研究  

Study on the Effect of Autistic Children's Auxiliary Intervention Based on Brain Functional Network Analysis

作　　者：李昕[1,2] 王欣 安占周 蔡二娟 康健楠 LI Xin;WANG Xin;AN Zhan-Zhou;CAI Er-Juan;KANG Jian-Nan(School of Electrical Engineering,Yanshan University,Qinhuangdao 066004;Measurement Technology and Instrumentation Key Lab of Hebei Province,Qinhuangdao 066004;College of Electronic Information Engineering,Hebei University,Baoding 071002)

机构地区：[1]燕山大学电气工程学院,秦皇岛066004 [2]河北省测试计量技术及仪器重点实验室,秦皇岛066004 [3]河北大学电子信息工程学院,保定071002

出　　处：《自动化学报》2021年第11期2654-2663,共10页Acta Automatica Sinica

基　　金：中国博士后科学基金(2014M550582);河北省自然科学基金(F2014203244,F2019203515)资助。

摘　　要：脑功能网络是分析复杂网络之间连接关系的一种有效方法,对脑功能障碍分析具有重要意义.本文基于频域Granger因果分析的定向传递函数(Direction-transfer function,DTF),构建了各频段的脑功能网络.采用图论方法分析最佳阈值下经颅直流电刺激(Transcranial direct current stimulation,tDCS)干预前后孤独症(Autism spectrum disorder,ASD)儿童脑网络的平均度、全局效率和平均局部效率等特征,并对比了经颅直流电刺激对孤独症儿童脑功能状态辅助干预效果.结果发现刺激前组在各频段的图论特征均低于刺激后组(P<0.05),其中Theta频段和低-beta频段的局部效率统计性差异显著,表明在一定程度上tDCS干预是ASD儿童治疗的有效手段.The brain functional network is an effective method to analyze the connection relationship between complexnetworks,which is of great significance to the analysis of brain dysfunction.In this paper,the brain function networkof each frequency band is constructed based on the direction-transfer function(DTF),of frequency domain Grangercausality analysis.Graph theory method was used to analyze the network average degree,global efficiency and averagelocal efficiency of brain network of autism spectrum disorder(ASD)children in two groups pre-/post-transcranial directcurrent stimulation(tDCS)under the optimal threshold values,and compare the auxiliary intervention effect of tDCS onbrain function status in ASD children.The results showed that the graph theory characteristics of the pre-tDCS groupwere lower than those of the post-tDCS group in each frequency band(P<0.05),and there were significant statisticaldifferences in local efficiency in'Theta and Low-beta bands.It is suggested that tDCS intervention is an effective methodfor the treatment of ASD children to a certain extent.

关 键 词：孤独症 经颅直流电刺激 脑功能网络 定向传递函数 

分 类 号：R749.94[医药卫生—神经病学与精神病学] O157.5[医药卫生—临床医学]