Hemolysis of PM_(10) on RBCs in vitro:An indoor air study in a coal-burning lung cancer epidemic area  

作　　者：Mengyuan Zhang Longyi Shao Tim Jones Ying Hu Rachel Adams Kelly BéruBé 

机构地区：[1]State Key Laboratory of Coal Resources and Safe Mining,and College of Geoscience and Surveying Engineering,China University of Mining&Technology,Beijing 100083,China [2]School of Earth and Environmental Sciences,Cardiff University,Museum Avenue,Cardiff CF103YE,UK [3]Guangdong Province Nuclear Industry Geological Bureau,Guangzhou 510800,China [4]School of Health Sciences,Cardiff Metropolitan University,Llandaff Campus,Western Avenue,Cardiff CF52YB,Wales,UK [5]School of Biosciences,Cardiff University,Museum Avenue,Cardiff CF103AX,Wales,UK

出　　处：《Geoscience Frontiers》2022年第1期506-511,共6页地学前缘（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC)(Grant Nos.42075107 and 41572090);the Yueqi Scholar fund of China University of Mining and Technology(Beijing)。

摘　　要：Epidemiological studies have suggested that inhalation exposure to indoor ambient air from coal-burning environments is causally associated with respiratory health risks.In order to explore the toxicological mechanisms behind the adverse health effects,the hemolytic activity of PM_(10)(particulate matter with an aerodynamic diameter of 10 um or less)samples collected from homes burning coal in the recognized China"cancer village"Xuanwei were evaluated and matched against their trace elemental contents.The results demonstrated that the hemolytic activity of indoor PM_(10) in coal-burning environments ranged from 4.28%to 5.24%,with a clear positive dose-response relationship.Although low dose samples exhibited a reduced hemolytic activity,PM_(10) could have a toxic effect upon people in a coal-burning indoor environment for extended time periods.The concentrations of analyzed trace elements in PM_(10) samples ranged from 6966 to 12,958 ppm.Among the analyzed elements,Zn,Ti,Ni,Cu,Pb,Ba,Mn,Cr and V were found at higher concentrations and accounted for over 95%of the total elements.The concentrations of total analyzed elements in the PM_(10) samples revealed a significant positive correlation with PM_(10) hemolytic activity.Of the analyzed elements,Zn,Pb and Cs positively correlated with hemolysis,while Li,U and V negatively correlated with the hemolysis of human red blood cells(RBCs).Therefore,the heavy metal elements could be one of the main factors responsible for the hemolytic capacity of indoor PM_(10) in coal-burning environments.

关 键 词：Air pollution PM_(10) COAL HEMOLYSIS Xuanwei County 

分 类 号：R734.2[医药卫生—肿瘤] X51[医药卫生—临床医学]