基于代谢组学技术的乳腺癌代谢产物研究进展  

Advances in metabolites of breast cancer based on metabolomics

作　　者：吴雪烁 冯景[1] 周毅[1] WU Xueshuo;FENG Jing;ZHOU Yi(Department of Breast Surgery,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,P.R.China)

机构地区：[1]哈尔滨医科大学附属第一医院乳腺外科,哈尔滨150001

出　　处：《中国普外基础与临床杂志》2021年第12期1661-1665,共5页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的对基于代谢组学技术的乳腺癌代谢产物的研究成果进行系统综述,以期为乳腺癌代谢研究提供新的方向。方法通过检索近年来相关文献,分析和总结代谢组学技术在识别乳腺癌高危人群、监测肿瘤进展情况和评估放化疗反应方面的应用。结果随着高分辨率、高敏感度和高通量生物分析平台技术的研发进展,代谢组学凭借其独特视角和技术优势,广泛应用于乳腺癌研究领域,能更精确、系统和动态地监测宿主代谢产物的变化规律。结论代谢组学技术为乳腺癌的一级预防、早期筛查诊断和优化治疗策略选择提供了新的研究方向。Objective To summarize the research results of metabolites of breast cancer based on metabonomics technology, and systematically reviews them in order to provide a new direction for the research of metabolism of breast cancer. Method By searching the relevant literatures in recent years, the application of metabonomics in identifying high-risk breast cancer population, monitoring the progress of tumor and evaluating the response of radiotherapy and chemotherapy were analyzed and summarized. Results With the development of high-resolution, high-sensitivity and high-throughput bioanalysis platform technology, metabolomics had been widely used in breast cancer research field by virtue of its unique perspective and technical advantages to more accurately, systematically and dynamically monitor the changes of host metabolites. Conclusion Metabolomics technology provides a new research direction for primary prevention, early screening and diagnosis of breast cancer and optimal treatment strategy selection.

关 键 词：乳腺癌 代谢组学 肿瘤微环境 

分 类 号：R737.9[医药卫生—肿瘤]