S100A10在抑郁症发病中的作用及其机制研究进展  

Research Progress on the Role and Mechanism of S100A10 in the Pathogenesis of Depression

作　　者：化瑞芳 张婧婧 丁彦 杨佩 刘荣勋 刘科锐 王辉 HUA Ruifang;ZHANG Jingjing;DING Yan;YANG Pei;LIU Rongxun;LIU Kerui;WANG Hui(Henan Key Laboratory of Immunology and Targeted Drugs,Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine,School of Laboratory Medicine,Xinxiang Medical University,Xinxiang 453003,China)

机构地区：[1]河南省免疫与靶向药物重点实验室,河南省分子诊断与医学检验技术协同创新中心,新乡医学院医学检验学院,新乡453003

出　　处：《中国细胞生物学学报》2021年第11期2261-2267,共7页Chinese Journal of Cell Biology

基　　金：国家高等学校学科创新引智计划(国家“111”计划)(批准号:D20036);国家自然科学基金(批准号:32000708);河南省自然科学基金(批准号:202300410314);河南省高等学校重点科研项目(批准号:21A310015)资助的课题。

摘　　要：抑郁症是一种慢性的可反复发作的精神类疾病,与大脑回路、神经网络、分子信号通路和神经递质等改变密切相关。S100A10蛋白是S100家族中的一员,在中枢神经系统包括前额叶皮层、海马、杏仁核等多个情绪调节的关键脑区中广泛表达,与五羟色胺受体、代谢型谷氨酸受体、脑源性神经营养因子等相互作用,在抑郁症的发病机制研究中备受关注。基于课题组多年来的研究和最新进展,该文就S100A10在抑郁症发病中的作用及其神经和分子机制进行综述,以期为S100A10在抑郁症发病中的进一步研究和临床疗效提供借鉴。Depression is a chronic and recurrent psychiatric disorder associating with the alterations of brain circuitries,neuronal networks,molecular signaling pathways and neurotransmitters.S100A10,a member of S100 family,is wildly expressed in the central nervous system,including prefrontal cortex,hippocampus,amygdala and other brain areas in emotion modulation.It interacts with serotonergic receptor,metabotropic glutamate receptor,brain-derived neurotrophic factor and so on.It has attracted much attention in the pathogenesis of depression.Based on the previous research and the recent insights,the focus of this review is to provide an update on the roles of S100A10 and its neural and molecular mechanism in the pathogenesis of depression,which provides new avenues for further research and clinical treatment.

关 键 词：抑郁症 S100A10 前额叶皮层 海马 杏仁核 五羟色胺受体 代谢性谷氨酸受体 脑源性神经营养因子 

分 类 号：R749.4[医药卫生—神经病学与精神病学]