左乙拉西坦与丙戊酸钠治疗伴中央-颞区棘波良性癫痫对照观察  

Controlled observation of levetiracetam and sodium valproate in the treatment of benign epilepsy with centrotemporal spikes

作　　者：郑华月[1] 张云涵[2] 郑春阳[3] Zheng Huayue;Zhang Yunhan;Zheng Chunyang(First author's address the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院,河南南阳473000 [2]南阳医学高等专科学校,河南南阳473000 [3]南阳医学高等专科学校第二附属医院,河南南阳473000

出　　处：《临床心身疾病杂志》2021年第6期137-139,150,共4页Journal of Clinical Psychosomatic Diseases

基　　金：南阳市科技发展计划项目(编号KJGG186)。

摘　　要：目的探讨左乙拉西坦与丙戊酸钠治疗伴中央-颞区棘波良性癫痫的疗效及对患儿认知功能的影响。方法将82例伴中央-颞区棘波良性癫痫患儿按随机数字表法分为两组,每组41例。对照组予以丙戊酸钠治疗,研究组予以左乙拉西坦治疗,观察16周。比较两组临床疗效、不良反应发生率、治疗前后中国韦氏儿童智力量表评分及P300潜伏期。结果两组总有效率比较差异无统计学意义(P>0.05)。治疗后研究组中国韦氏儿童智力量表的语言智商、操作智商及总智商评分显著高于对照组(P<0.05),P300潜伏期显著短于对照组(P<0.05)。研究组不良反应发生率显著低于对照组(P<0.05)结论左乙拉西坦与丙戊酸钠治疗伴中央-颞区棘波良性癫痫患儿疗效均较好且相当,但左乙拉西坦对认知功能的改善效果更好,安全性更高。Objective To investigate the effect of levetiracetam and sodium valproate in the treatment of benign epilepsy with centrotemporal spikes and its influence on children's cognitive function.Methods A total of 82 children with benign epilepsy with centrotemporal spikes were divided into two groups according to random number table method,with 41 cases in each group.The control group was treated with sodium valproate and the study group was treated with levetiracetam foR16 weeks.The clinical efficacy,incidence of adverse reactions,Chinese Wechsler intelligence scale for children(C-WISC)score and P300 latency before and after treatment were compared between the two groups.Results There was no significant difference in the total effective rate between the two groups(P>0.05).After treatment,the linguistic IQ,performance IQ and total IQ scores of C-WISC in the study group were significantly higher than those in the control group(P<0.05),P300 latency were shorter than those of control group(P<0.05).The incidence of adverse reactions in the study group was significantly lower than that in the control group(P<0.05).Conclusions Levetiracetam and sodium valproate are effective and equivalent in the treatment of children with benign epilepsy with centrotemporal spikes,but levetiracetam has better effect and higher safety in improving cognitive function.

关 键 词：癫痫 中央-颞区棘波 左乙拉西坦 疗效 认知功能 丙戊酸钠 脑电图 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]