胶质瘤炎性适应免疫:Toll样受体与趋化因子的作用  

Inflammatory adaptive immunity in gliomas:roles of Toll-like receptors and chemokines

作　　者：解祥通 闫可 费喜峰[1] 孟璇 朱文昱 王之敏[1] 黄强[3] Xie Xiangtong;Yan Ke;Fei Xifeng;Meng Xuan;Zhu Wenyu;Wang Zhimin;Huang Qiang(Department of Neurosurgery,Suzhou Kowloon Hospital,School of Medicine,Shanghai Jiaotong University,Suzhou 215021,China;Department of Neurosurgery,Affiliated Suzhou Science&Technology Town Hospital,Nanjing Medical University,Suzhou 215163,China;Department of Neurosurgery,,Second Affiliated Hospital ofSoochow University,Suzhou 215004,China)

机构地区：[1]上海交通大学医学院苏州九龙医院神经外科,苏州215021 [2]南京医科大学附属苏州科技城医院神经外科,苏州215163 [3]苏州大学附属第二医院神经外科,苏州215004

出　　处：《中华神经医学杂志》2021年第12期1264-1269,共6页Chinese Journal of Neuromedicine

基　　金：苏州市医疗卫生科技创新项目(SKY2021028);苏州市姑苏卫生人才项目(GSWS2020122);苏州九龙医院青年预研基金(SZJL202102);苏州工业园区培育项目(SZJL201901)。

摘　　要：癌症与适应免疫关系的研究正在向纵深发展,其标志之一是通过高通量分子生物信息学分析,来优选调控适应免疫的关键分子及其通路。癌症是一种非可控的炎症,适应免疫相关细胞是驱动可控性炎症向非可控性发展的主要成员,其分子调控机制研究是当今的热门话题。本文围绕这些适应免疫相关细胞呈非可控性生长(恶变)的深度测序数据库、生物信息学分析到的一些Toll样受体(TLRs)与趋化因子的研究进展进行综述。The research on relation between cancer and adaptive immunity is developing in depth.One of its signs is to optimize the key molecules and their pathways for regulating adaptive immunity through high-throughput molecular bioinformatics analysis.Based on the fact that cancer is an uncontrolled inflammation,adaptive immune-related cells are the main members driving the development of controllable inflammation to non-controllable inflammation,and the research on its molecular regulatory mechanism is a hot topic nowadays.Based on the in-depth sequencing database and bioinformatics analysis of the non-controllable growth(malignant transformation)of these adaptive immune-related cells,the research progress of Toll-like receptors and chemokines is summarized as follows.

关 键 词：TOLL样受体 趋化因子 生物信息学 适应免疫 

分 类 号：R739.41[医药卫生—肿瘤]