外泌体在帕金森病中的研究进展  

Recent advance in exosomes in Parkinson’s disease

作　　者：周丽娜[1] 王洪新[1] Zhou Lina;Wang Hongxin(Department of Neurology,Fourth Center Hospital of Tianjin,Tianjin 300140,China)

机构地区：[1]天津市第四中心医院神经内科,300140

出　　处：《中华神经医学杂志》2021年第12期1270-1274,共5页Chinese Journal of Neuromedicine

基　　金：天津市卫生健康科技项目(ZC20110)

摘　　要：外泌体能穿透血脑屏障,在外周循环中高度稳定并很好地保护疾病相关分子,所以可以用来监测疾病的发展,优化早期诊断和治疗。利用外泌体作为PD等中枢神经系统疾病的生物标志物前景广阔.本文现围绕外泌体在P D中的病理生理作用以及作为P D生物标志物的研究进展综述如下。Exosomes can penetrate the blood-brain barrier and are highly stable in the peripheral circulation,which can protect disease-related molecules,so they can be used to monitor the development of disease and optimize early diagnosis and treatment.Therefore,the use of exosomes as biomarkers of central nervous system diseases is very promising.This article reviews the pathophysiological role of exosomes in Parkinson's disease and the research progress of exosomes as biomarkers of Parkinson's disease.

关 键 词：帕金森病 外泌体 生物标志物 

分 类 号：R742.5[医药卫生—神经病学与精神病学]