ω-3鱼油脂肪乳对胃癌患者术后肝肾功能及预后的影响  

Effect ofω-3 fish oil fat emulsion on postoperative liver and renal functions and prognosis in patients with gastric cancer

作　　者：徐晓文 李园园[2] XU Xiaowen;LI Yuanyuan(Clinical Trial Office,Nanjing Hospital Affiliated to Nanjing Medical University,the First Hospital of Nanjing City in Jiangsu Province,Nanjing,Jiangsu,210006;Department of Pharmacy,Nanjing Hospital Affiliated to Nanjing Medical University,the First Hospital of Nanjing City in Jiangsu Province,Nanjing,Jiangsu,210006)

机构地区：[1]南京医科大学附属南京医院/江苏省南京市第一医院临床试验办公室,江苏南京210006 [2]南京医科大学附属南京医院/江苏省南京市第一医院药学部,江苏南京210006

出　　处：《实用临床医药杂志》2021年第20期42-45,51,共5页Journal of Clinical Medicine in Practice

基　　金：南京药学会—常州四药医院药学科研基金资助课题(2019YX028)。

摘　　要：目的探讨ω-3鱼油脂肪乳对胃癌患者术后肝肾功能及预后的影响。方法采用回顾性队列研究方法,收集南京市第一医院普外科2018年1月—2019年12月126例胃癌术后患者的资料,并将患者随机分为对照组(肠外营养中应用常规脂肪乳)和观察组(对照组基础上加用ω-3鱼油脂肪乳),每组63例。比较2组患者术前1 d和术后7 d的肝肾功能指标[谷氨酸-丙酮酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、总胆红素(TBIL)、肌酐(Cr)、血尿素氮(BUN)]、营养指标[总蛋白(TP)和白蛋白(ALB)]和血脂指标[甘油三酯(TG)和总胆固醇(TC)]。比较2组住院时间、术后住院时间、术后并发症和术后通气时间。结果观察组术后7 d的ALT、TBIL和TG水平低于对照组,ALB高于对照组,差异有统计学意义(P<0.05)。2组患者住院时间、术后住院时间、通气时间和术后并发症比较,差异无统计学意义(P>0.05)。结论ω-3鱼油脂肪乳可改善患者肝功能、脂肪代谢,减少ALB降低幅度,但在缩短住院时间、减少并发症和改善肾功能方面未观察到明显的优势。Objective To explore the effect ofω-3 fish oil fat emulsion on postoperative liver and renal functions and prognosis in patients with gastric cancer.Methods A retrospective cohort study was adopted,and the materials of 126 patients after gastric cancer surgery from January 2018 to December 2019 in the Department of General Surgery in the First Hospital of Nanjing City were collected.All the patients were randomly divided into control group(treated with routine fat emulsion in parenteral nutrition)and observation group(treated with additionalω-3 fish oil fat emulsion on the basis of control group),with 63 cases in each group.At the time points of one day before operation and 7 days after operation,the indexes of liver and renal functions[alanine transaminase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),creatinine(Cr),blood urea nitrogen(BUN)],nutritional indexes[total protein(TP)and albumin(ALB)]and blood lipid indexes[triglyceride(TG)and total cholesterol(TC)]were compared between the two groups.The hospital stay,postoperative hospital stay,postoperative complications and postoperative ventilation time were compared between the two groups.Results Levels of ALT,TBIL and TG at 7 days after operation in the observation group were significantly lower than those in the control group,while ALB level was significantly higher than that in the control group(P<0.05).There were no significant differences in hospital stay,postoperative hospital stay,ventilation time and postoperative complications between the two groups(P>0.05).Conclusionω-3 fish oil fat emulsion can improve liver function and fat metabolism of patients,reduce the reduction range of ALB,but shows no obvious advantages in shortening hospital stay,reducing complications and improving renal function.

关 键 词：胃癌 Ω-3鱼油脂肪乳 肝肾功能 并发症 总胆红素 白蛋白 

分 类 号：R735.2[医药卫生—肿瘤] R591[医药卫生—临床医学]