白蛋白结合型紫杉醇联合铂类药物治疗头颈肿瘤的疗效及对自然杀伤细胞活性的影响  

Efficacy of nanoparticle albumin-bound paclitaxel combined with platinum drugs in treatment of head and neck tumors and its influence on activity of natural killer cells

作　　者：王娟[1] 葛方红 曹剑锋 何云华[1] 单桂芹 WANG Juan;GE Fanghong;CAO Jianfeng;HE Yunhua;SHAN Guiqin(Department of Oncology,Tongzhou Hospital Affiliated to Nantong University,Nantong,Jiangsu,226300;Department of Radiotherapy,Tumor Hospital Affiliated to Nantong University,Nantong,Jiangsu,226361)

机构地区：[1]南通大学附属通州医院肿瘤科,江苏南通226300 [2]南通大学附属肿瘤医院放疗科,江苏南通226361

出　　处：《实用临床医药杂志》2021年第20期52-55,共4页Journal of Clinical Medicine in Practice

基　　金：江苏省南通市卫生和计划生育委员会科研课题项目(QA2019053)。

摘　　要：目的探讨白蛋白结合型紫杉醇(nab-PTX)联合铂类治疗头颈肿瘤的疗效及对自然杀伤(NK)细胞活性的影响。方法将75例头颈肿瘤患者随机分为2组,对照组(n=38)采用紫杉醇(PTX)联合铂类治疗,观察组(n=37)采用nab-PTX联合铂类治疗。比较2组不同时点疾病控制率(DCR)、NK细胞活性、毒副反应。随访1年,比较2组患者生存率。结果观察组治疗后1、2、4个周期的疾病控制率均高于对照组,差异有统计学意义(P<0.05)。观察组周围神经炎、腹泻、恶心呕吐、白细胞减少、血小板减少等毒副反应发生率低于对照组,差异有统计学意义(P<0.05)。观察组治疗后2、4个周期时NK细胞活性均高于对照组,差异有统计学意义(P<0.05)。随访1年时,观察组生存率高于对照组,生存时间长于对照组,差异有统计学意义(P<0.05或P<0.01)。结论头颈肿瘤患者接受nab-PTX联合铂类治疗的效果显著,可延长生存期,提高NK细胞活性,降低不良反应发生率。Objective To explore the efficacy of nanoparticle albumin-bound paclitaxel(nab-PTX)combined with platinum drugs in the treatment of head and neck tumors and its influence on the activity of natural killer(NK)cells.Methods Totally 75 patients with head and neck tumors were randomly divided into two groups.Control group(n=38)was treated with paclitaxel(PTX)and platinum drugs,while observation group(n=37)was treated with nab-PTX and platinum drugs.The disease control rate(DCR),activity of NK cells as well as toxic and side effects were compared between the two groups at different time points.After a year of follow up,the survival rate of the two groups was compared.Results The DCR of the observation group in 1 cycle,2 and 4 cycles after treatment was significantly higher than that of the control group(P<0.05).The incidence rates of toxic and side effects such as peripheral neuritis,diarrhea,nausea and vomiting,leucopenia and thrombocytopenia in the observation group were significantly lower than that in the control group(P<0.05).The activity of NK cells in the observation group was significantly higher than that in the control group at 2 and 4 cycles after treatment(P<0.05).After a year of follow-up,the survival rate of the observation group was significantly higher than that of the control group,and the survival time was significantly longer than that of the control group(P<0.05 or P<0.01).Conclusion The efficacy of nab-PTX combined with platinum drugs therapy is significant in patients with head and neck tumors,which can prolong the survival time,improve the activity of NK cells and reduce the incidence of adverse reactions.

关 键 词：白蛋白结合型紫杉醇 紫杉醇 铂类药物 头颈肿瘤 化疗 

分 类 号：R739.9[医药卫生—肿瘤] R961[医药卫生—临床医学]