肠道微生态干预对结肠癌患者术后及化疗期间并发症的影响  

Effect of intestinal microecological intervention on complications after operation and during chemotherapy in patients with colon cancer

作　　者：陈意良 张银旭 车忠广 CHEN Yiliang;ZHANG Yinxu;CHE Zhongguang(Graduate Training Base of Jinzhou Medical University,Dandong Central Hospital of Liaoning Province,Dandong,Liaoning,118000;the First Hospital Affiliated to Jinzhou Medical University,Jinzhou,Liaoning,121000)

机构地区：[1]锦州医科大学研究生培养基地/辽宁省丹东市中心医院,辽宁丹东118000 [2]锦州医科大学附属第一医院,辽宁锦州121000

出　　处：《实用临床医药杂志》2021年第20期73-77,共5页Journal of Clinical Medicine in Practice

摘　　要：目的探讨围术期及化疗期全程肠道微生态干预对结肠癌患者术后及化疗期间并发症的影响。方法选取79例结肠癌患者作为研究对象,依据是否全程应用双歧杆菌三联活菌片将患者分为干预组40例和对照组39例。对照组常规行结肠癌根治术及化疗,干预组在对照组基础上从术前5 d开始服用双歧杆菌三联活菌片,直至化疗期结束。比较2组患者术后胃肠功能恢复情况、并发症发生情况,并比较2组术后及化疗期间血清炎症反应指标水平。结果干预组患者术后恢复肛门排气、排便时间早于对照组,差异有统计学意义(P<0.05);干预组患者术后并发症总发生率和化疗期间各并发症发生率均低于对照组,差异有统计学意义(P<0.05);干预组患者术后及化疗期间的血清炎症指标水平均低于对照组,差异有统计学意义(P<0.05)。结论结肠癌患者围术期及术后化疗期间全程服用双歧杆菌三联活菌片,可明显缩短术后胃肠功能恢复时间,同时有利于抑制炎症,减少术后及化疗期间并发症的发生,促进疾病转归。Objective To investigate the effect of whole-course intestinal microecological intervention intestinal microecological intervention on complications after operation and during chemotherapy in patients with colon cancer.Methods Seventy-nine patients with colon cancer were selected as study objects and were divided into intervention group(n=40)and control group(n=39)according to whether patients were treated with Bifidobacterium Triple Viable Bacteria Tablets.The control group received conventional radical resection of colon cancer and chemotherapy,and the intervention group received Bifidobacterium Triple Viable Bacteria Tablets from 5 days before surgery until the end of chemotherapy.Postoperative recovery of gastrointestinal function and occurrence of complications in both groups were recorded.Serum inflammatory response indexes were compared after operation and during chemotherapy.Results The postoperative recovery time of anal exhaust and defecation time in the intervention group were significantly shorter compared with the control group(P<0.05).The overall incidence of postoperative complications and the incidence of various types of complications during chemotherapy in the intervention group were lower than those in the control group(P<0.05).Serum inflammatory indexes in the intervention group after surgery and during chemotherapy were significantly lower than those in the control group(P<0.05).Conclusion The administration of Bifidobacterium Triple Viable Bacteria Tablets for colon cancer patients during period of perioperation and chemotherapy can significantly shorten the time of postoperative gastrointestinal function recovery,and at the same time,it is beneficial to suppress inflammation,reduce the incidence of complications after radical resection of colon cancer and during chemotherapy,and help to promote the outcome of the disease.

关 键 词：结肠癌 肠道微生态 益生菌 术后并发症 化疗并发症 

分 类 号：R735.3[医药卫生—肿瘤] R730.5[医药卫生—临床医学]