奥美拉唑结合黄连素、二甲双胍在慢性胃炎伴糖尿病患者治疗中的应用  

Application of Omeprazole Combined with Berberine and Metformin in the Treatment of Patients with Chronic Gastritis and Diabetes

作　　者：魏则梁 WEI Zeliang(Department of Gastroenterology,Songkou Branch,Yongtai County General Hospital,Fuzhou,Fujian Province,350706 China)

机构地区：[1]永泰县总医院嵩口分院消化内科,福建福州350706

出　　处：《糖尿病新世界》2021年第21期27-31,共5页Diabetes New World Magazine

摘　　要：目的分析奥美拉唑结合黄连素应用于慢性胃炎伴糖尿病(diabetes mellitus,DM)患者的治疗效果。方法选取2019年1月—2021年1月该院就诊的慢性胃炎伴DM患者180例作研究对象加以分析,现循随机分组原则分作对照组及观察组,每组90例。以上患者均采取常规糖尿病治疗,对照组采取奥美拉唑药物联合米格列奈钙片进行治疗,观察组采取奥美拉唑结合黄连素药物、二甲双胍进行治疗,比较两组空腹血糖(fasting blood glucose,FPG)和餐后2h血糖(2 hPG)数值;统计两组临床疗效;对比两组治疗不良反应。结果治疗前,两组患者FPG、2 hPG水平,差异无统计学意义(P>0.05);治疗后,两组患者以上2项血糖数值均有所下降,观察组血糖数值水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组血糖控制率为96.67%,高于对照组的87.78%,差异有统计学意义(P<0.05);观察组治疗总有效率为97.78%,明显高于对照组的90.00%,差异有统计学意义(P<0.05);观察组不良反应(恶心、口干、头晕等)发生率为3.33%,低于对照组的11.11%,差异有统计学意义(P<0.05)。结论奥美拉唑结合黄连素、二甲双胍治疗慢性胃炎伴DM可起到显著降糖效果,促进胰岛功能恢复和胃功能恢复,利于血糖控制,降低不良反应发生率,加强治疗疗效,利于疾病的恢复。Objective The therapeutic effect of omeprazole combined with berberine in patients with chronic gastritis and diabetes(diabetes mellitus, DM). Methods A total of 180 patients with chronic gastritis and DM who were treated in the hospital from January 2019 to January 2021 were selected as the research subjects for analysis. Now they were divided into the control group and the observation group according to the principle of randomization, with 90 cases in each group. The above patients were treated with conventional diabetes. The control group was treated with omeprazole combined with Miglinide calcium tablets, and the observation group was treated with omeprazole combined with berberine and metformin.The fasting blood glucose(FPG) and postprandial 2 h blood glucose(2 hPG) values were compared between the two groups;the clinical effects of the two groups were counted;the adverse reactions of the two groups were compared. Results Before treatment, there was no statistically significant difference in FPG and 2 hPG levels between the two groups(P>0.05). After treatment, the above two blood glucose values of the two groups of patients decreased. The blood glucose level of the observation group was lower than that of the control group, and the difference was statistically significant(P<0.05). After treatment, the blood glucose control rate in the observation group was 96.67%, which was higher than 87.78% in the control group, and the difference was statistically significant(P<0.05). The total effective rate of treatment in the observation group was 97.78%, which was significantly higher than 90.00%in the control group, and the difference was statisticallysignificant(P<0.05). The incidence of adverse reactions(nausea, dry mouth, dizziness, etc.) was 3.33% in the observation group, which was lower than 11.11% in the control group. The difference was statistically significant(P<0.05). Conclusion Omeprazole combined with berberine and metformin in the treatment of chronic gastritis with DM can have a significant hypoglycemi

关 键 词：奥美拉唑 黄连素 慢性胃炎伴糖尿病 

分 类 号：R573[医药卫生—消化系统]