Impact of thymosinα1 as an immunomodulatory therapy on long-term survival of non-small cell lung cancer patients after R0 resection:a propensity score-matched analysis  

作　　者：Cheng-Lin Guo Jian-Dong Mei Yu-Long Jia Fan-Yi Gan Yu-Dong Tang Cheng-Wu Liu Zhen Zeng Zhen-Yu Yang Sen-Yi Deng Xing Sun Lun-Xu Liu 

机构地区：[1]Department of Thoracic Surgery and Institute of Thoracic Oncology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer,Chengdu,Sichuan 610041,China [3]Chinese Evidence-Based Medicine Centre,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China.

出　　处：《Chinese Medical Journal》2021年第22期2700-2709,共10页中华医学杂志（英文版）

基　　金：1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(Nos.ZYGD18021 and ZYJC18009).

摘　　要：Background:There is limited information about thymosinα1(Tα1)as adjuvant immunomodulatory therapy,either used alone or combined with other treatments,in patients with non-small cell lung cancer(NSCLC).This study aimed to evaluate the effect of adjuvant Tα1 treatment on long-term survival in margin-free(R0)-resected stage IA–IIIA NSCLC patients.Methods:A total of 5746 patients with pathologic stage IA-IIIA NSCLC who underwent R0 resection were included.The patients were divided into the Tα1 group and the control group according to whether they received Tα1 or not.A propensity score matching(PSM)analysis was performed to reduce bias,resulting in 1027 pairs of patients.Results:After PSM,the baseline clinicopathological characteristics were similar between the two groups.The 5-year disease-free survival(DFS)and overall survival(OS)rates were significantly higher in the Tα1 group compared with the control group.The multivariable analysis showed that Tα1 treatment was independently associated with an improved prognosis.A longer duration of Tα1 treatment was associated with improved OS and DFS.The subgroup analyses showed that Tα1 therapy could improve the DFS and/or OS in all subgroups of age,sex,Charlson Comorbidity Index(CCI),smoking status,and pathological tumor-node-metastasis(TNM)stage,especially for patients with non-squamous cell NSCLC and without targeted therapy.Conclusion:Tα1 as adjuvant immunomodulatory therapy can significantly improve DFS and OS in patients with NSCLC after R0 resection,except for patients with squamous cell carcinoma and those receiving targeted therapy.The duration of Tα1 treatment is recommended to be>24 months.

关 键 词：Non-small cell lung cancer RESECTION Adjuvant therapy Thymosinα1 

分 类 号：R734.2[医药卫生—肿瘤]