Gene expression profiles of peripheral blood mononuclear cells from patients with atopic dermatitis stimulated with Malassezia globosa  

作　　者：Mao Lu Ya-Ling Dai Xin Ran Sushmita Pradhan Hai-Rong Liu Mei Ou Hong-Mei Wu Yu-Ping Ran 

机构地区：[1]Department of Dermatovenereology,Sichuan University West China Hospital,Chengdu,Sichuan 610041,China [2]Department of Dermatovenereology,The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,China [3]Department of Laboratory Medicine,The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,China.

出　　处：《Chinese Medical Journal》2021年第22期2759-2761,共3页中华医学杂志（英文版）

基　　金：the Research Project of Sichuan Provincial Education Department(No.17ZA0127);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,and the HX-Academician Project,West China Hospital,Sichuan University.

摘　　要：To the Editor:Malassezia located in the skin of patients with atopic dermatitis(AD)might be related to its pathogenesis,consisting of Malassezia globosa and Malassezia restricta as the dominant species.[1]However,the specific molecular mechanisms of Malassezia on host immune cells from AD patients are still unclear.In our study,the Affymetrix Human Prime View array was used to detect the effect of M.globosa on the gene expression of peripheral blood mononuclear cells(PBMCs)from AD patients,which was favorable to further understand the role of Malassezia colonization in the pathogenesis of AD.

关 键 词：PATIENTS DERMATITIS PATHOGENESIS 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]