噬菌体与牙周病原菌相互作用对牙周病影响的研究进展  

Research progress on the effects of the interactions between phage and periodontal pathogens on periodontal disease

作　　者：刘桢 张子健 何科泰 黄睿洁 Liu Zhen;Zhang Zijian;He Ketai;Huang Ruijie(Department of Pediatric Dentistry,West China Hospital of Stomatology,Sichuan University&State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Other Research Platforms,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院儿童口腔科,口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,成都610041

出　　处：《中华口腔医学杂志》2021年第12期1282-1286,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金(31800114)。

摘　　要：牙周病是最常见的口腔疾病之一。噬菌体作为感染细菌的病毒,是口腔微生物组的重要组成部分。随着生物信息学与基因组学的发展,噬菌体、口腔微生态、牙周病三者间的具体关系正在被逐渐揭示。噬菌体疗法也因此成为对抗超级细菌的新方法,近年来蓬勃发展。本文综述了口腔噬菌体与牙周病相关的微生物作用机制、噬菌体在维持牙周正常环境中的作用、噬菌体失衡与牙周病发生发展的关系以及噬菌体在牙周疾病治疗中的应用。本文为噬菌体对牙周病影响机制的深入研究以及噬菌体疗法的进一步临床应用提供参考。Periodontal disease is among the most prevalent oral diseases.As viruses that may infect bacteria,bacteriophages constitute an important component of the oral microbiome.With the advances in bioinformatics and genomics,the relationships among the bacteriophages,oral microbiome and periodontal disease is gradually being elucidated.As a result,phage therapy has become an emerging approach in the fight against super bacteria and has flourished in recent years.This review article discusses the mechanisms involved in the microbial interactions associated with oral phages and periodontal disease,the role of phages in maintaining a normal periodontal environment,the relationship between the imbalance of phages and the occurrence of periodontal disease,and the use of phage in the treatment of periodontal disease in order to provides references for in-depth research on the mechanisms of phage effects on periodontal disease,as well as the further clinical application of phage therapy.

关 键 词：牙周炎 噬菌体 口腔微生态 微生物间相互作用 

分 类 号：R781.4[医药卫生—口腔医学]