双相障碍患者血清PRL、IL-6、甲状腺功能和执行功能变化的临床意义分析  

Analysis on clinical significance of changes of serum PRL,IL-6,thyroid function and executive function in patients with bipolar disorder

作　　者：王金成[1] 殷慧[1] 刘玉梅 苏冠丽[1] 周亚婷[1] 孟丽敏[1] 王冉[1] 宋美[1] WANG Jincheng;YIN Hui;LIU Yumei;SU Guanli;ZHOU Yating;MENG Limin;WANG Ran;SONG Mei(Mental Health Center,the First Hospital of Hebei Medical University,Shijiazhuang,Hebei 050031,China)

机构地区：[1]河北医科大学第一医院精神卫生中心,河北石家庄050031

出　　处：《国际检验医学杂志》2022年第1期36-41,共6页International Journal of Laboratory Medicine

基　　金：河北省医学科学研究课题(20201144)。

摘　　要：目的探讨双相障碍患者治疗前后血清催乳素(PRL)和白细胞介素-6(IL-6)水平、甲状腺功能和执行功能的变化情况,分析其与患者病情的关系。方法选取2018年5月至2020年5月该院收治的150例双相障碍患者为研究对象,将其中71例抑郁发作患者纳入双相抑郁组,79例躁狂发作患者纳入双相躁狂组,另选该院同期50例体检健康者纳入健康组。比较3组血清PRL、IL-6、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)水平和威斯康星卡片分类测验(WCST)各维度结果,比较治疗前后双相抑郁组汉密尔顿抑郁量表24项版(HAMD-24)评分及双相躁狂组贝克-拉范森躁狂量表(BRMS)评分,并分析血清PRL、IL-6、T3、T4、TSH水平和WCST各维度结果与HAMD-24、BRMS评分的相关性。结果治疗前双相抑郁组、双相躁狂组及健康组入组时血清PRL、IL-6、T3、T4、TSH水平和WCST各维度结果比较,差异有统计学意义(P<0.05);治疗后双相抑郁组和双相躁狂组前述各指标较治疗前改善,差异均有统计学意义(P<0.05),且双相抑郁组、双相躁狂组、健康组前述各指标差异无统计学意义(P>0.05)。治疗后双相抑郁组HAMD-24评分和双相躁狂组BRMS评分低于治疗前,差异均有统计学意义(P<0.05)。双相抑郁组血清PRL、IL-6、TSH水平及WCST错误数、非持续性错误数、持续性错误数与HAMD-24评分呈正相关(P<0.05),而血清T3、T4水平及WCST正确数、分类数与HAMD-24评分呈负相关(P<0.05);双相躁狂组血清PRL、IL-6、T3、T4水平及WCST错误数、非持续性错误数、持续性错误数与BRMS评分呈正相关(P<0.05),而血清TSH水平及WCST正确数、分类数与BRMS评分呈负相关(P<0.05)。结论双相障碍患者血清PRL、IL-6、T3、T4、TSH水平和执行功能治疗前后变化明显,且与患者临床症状评分相关,有望成为双相障碍患者症状改善及疗效判定的辅助评估指标。Objective To investigate the changes of serum prolactin(PRL)and interleukin-6(IL-6),thyroid function and executive function in patients with bipolar disorder before and after treatment,and analyze the relationship between them and the clinical symptom scores of the patients.Methods A total of 150 patients with bipolar disorder admitted to the hospital from May 2018 to May 2020 were selected as the research objects.Among them,71 patients with depressive episodes were included in the bipolar depression group,and 79 patients with manic episodes were included in the bipolar mania group.In addition,50 healthy people undergoing physical examinations from the hospital during the same period were included in the health group.The levels of serum PRL,IL-6,triiodothyronine(T3),thyroxine(T4),thyroid stimulating hormone(TSH)and Wisconsin card sorting test(WCST)results in various dimensions were compared.The scores of Hamilton depression scale 24 item version(HAMD-24)in the bipolar depression group and Bech-Rafaelsdn mania rating scale(BRMS)in the bipolar mania group were compared before and after treatment,and the correlation between the levels of serum PRL,IL-6,T3,T4,TSH and WCST results in various dimensions with the scores of HAMD-24 and BRMS was analyzed.Results Before treatment,the results of serum PRL,IL-6,T3,T4,TSH levels and WCST in the bipolar depression group,bipolar mania group and healthy group were compared,and the differences were statistically significant(P<0.05).After treatment,the aforementioned indicators in the bipolar depression group and the bipolar mania group were improved compared to before treatment,and the differences were statistically significant(P<0.05).There was no statistical signifcance in the difference of the aforementioned indicators in the bipolar depression group,the bipolar mania group,and the healthy group(P>0.05).After treatment,the HAMD-24 score in the bipolar depression group and the BRMS score in the bipolar mania group were lower than the scores before treatment,and the difference w

关 键 词：双相障碍 催乳素 白细胞介素-6 甲状腺功能 执行功能 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R446.9[医药卫生—临床医学]