5-羟色胺运载蛋白基因启动子区多态性与银屑病遗传易感性的研究  

Association between 5-Serotonin Transporter Gene Polymorphism and Psoriasis Vulgaris

作　　者：陶喆 王玉鹏 黎威巍 陈舒丽 单士刚 包永芬 TAO Zhe;WANG Yu-peng;BAO Yong-fen(School of Pharmacy,Hubei University of Science and Technology,Xianning Hubei 437100,China)

机构地区：[1]湖北科技学院药学院,湖北咸宁437100 [2]湖北科技学院临床医学院 [3]湖北科技学院基础医学院

出　　处：《湖北科技学院学报（医学版）》2021年第6期505-508,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：2015年湖北省教育厅人文社会科学研究资助项目(15Q226);2018年咸宁市科技计划项目(2019kj12);湖北科技学院校内科研发展基金项目(2019-20X019);国家级大学生创新创业训练计划项目(201810927004)。

摘　　要：目的初步探讨5-羟色胺(5-HT)运载蛋白基因启动子区多态性与寻常型银屑病遗传易感性的关系。方法采用病例对照研究方法,使用聚合酶链式反应扩增寻常型银屑病患者(观察组)和健康人(对照组)5-HT基因的启动子区(5-HTTLPR)位点,以琼脂糖凝胶电泳分离法进行基因分型。结果基因型LL、LS、SS在病例组中的频率分别为36.0%、47.0%、17.0%,在对照组中的频率分别为38.7%、46.0%、15.3%。两组间基因型频率分布没有显著性差异(P>0.05);观察组及对照组内不同性别间基因型分布的差异均无统计学意义(P>0.05)。结论5-HTTLPR位点在中国汉族人群寻常型银屑病发病机制中可能不起主要作用。Objective To explore the association between 5-serotonin transporter gene polymorphism(SLG6A4)and psoriasis vulgaris(PV).Methods Case-control study was adopted,and all the subjects were genotyped directly by using polymerase chain reaction amplification fragment length polymorphism techniques and agarose gel electrophoresis method.Results There were no significant differences between patients and control group in the SLC6A4 intron 2 long/long(L/L)genotype,long/short genotype and short/short(S/S)genotype(36%vs 38.7%;47%vs 46%;17%vs 15.3%).(P>0.05).There was no significant difference for the genotype of SLC6A4 in different gender between the two groups(P>0.05).Conclusion The polymorphism of 5-HTTLPR sites may not play a vital role in PV in Chinese Han population.

关 键 词：寻常型银屑病 多态性 5-羟色胺转运体 

分 类 号：R749.5[医药卫生—神经病学与精神病学]