缩氨基硫脲衍生物的合成及抗菌活性研究  

Synthesis and Antibacterial Activities of Thiosemicarbazone Derivatives

作　　者：刘海彬[1] 吕萍[1] LIU Hai-bin;LV Ping(School of Biomedical & Chemical Engineering, Liaoning Institute of Science and Technology, Benxi 1170041, China)

机构地区：[1]辽宁科技学院生物医药与化学工程学院,辽宁本溪117004

出　　处：《合成化学》2021年第12期1065-1070,共6页Chinese Journal of Synthetic Chemistry

基　　金：辽宁省博士科研项目启动基金计划项目(2019-BS-129)。

摘　　要：以邻甲苯胺、苯胺或乙醇胺和二硫化碳为原料,经与氨水、氯乙酸钠和水合肼反应,合成了N(4)取代氨基硫脲,再与取代水杨醛或2-乙酰基吡啶进行缩合反应,得到6个缩氨基硫脲化合物3a~3f。抗菌实验结果表明:当质量浓度为1 mg/mL时,化合物3d对革兰氏阳性菌—金黄色葡萄球菌和枯草芽孢杆菌有很强的抑菌活性,对革兰氏阴性菌-大肠杆菌有一定的抑菌活性。Substituted N(4)thiosemicarbazide was synthesized from o-toluidine aniline or ethanolamine and CS_(2) by reaction with NH_(3)·H_(2)O,ClCH_(2)COONa and N_(2)H_(4)·H_(2)O.Then six N(4)thiosemicarbazide compounds 3a~3f were synthesized by condensation with substituted salicylaldehyde or 2-acetylpyridine.The results of antibacterial test showed that the compound 3d had strong antibacterial activity against gram positive microbes of S.Aureus and B.subtilis,and had certain inhibitory activity against Gram negative bacteria of E.Coli at the concentration of 1 mg/mL.

关 键 词：3 5-二溴水杨醛 缩氨基硫脲 生物活性 合成 苯胺 水合肼 

分 类 号：O625[理学—有机化学]