基于数据挖掘的中医治疗湿疹用药规律分析  

Analysis of medication regularity of traditional Chinese medicine in eczema treatment based on data mining

作　　者：邵海峰 杨妞妞 刘延庆 SHAO Haifeng;YANG Niuniu;LIU Yanqing(Yangzhou University,Yangzhou,Jiangsu,225009)

机构地区：[1]扬州大学,江苏扬州225009

出　　处：《实用临床医药杂志》2021年第24期83-86,96,共5页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金青年科学基金项目(81904212);中国博士后科学基金第13批特别资助(站中)(2020T130562);江苏省高等学校自然科学研究面上项目(18KJB360016);江苏省中医药科技发展计划(YB201995)。

摘　　要：目的基于数据挖掘技术分析中医药治疗湿疹的组方用药规律。方法检索收集中文期刊全文数据库(CNKI)、万方学术期刊全文数据库近20年内1 214篇中医药治疗湿疹的期刊文献,使用Excel软件建立数据库,分析用药频次与高频药物性味归经分布;分析湿疹伴瘙痒剧烈时辨证用药规律;使用Spss Modeler软件基于关联规则Apriori算法挖掘湿疹治疗用药的关联规则及处方规律,并进行网络可视化分析。结果本研究共纳入584篇文献,970首方剂,涉及中草药454味。其中内服汤剂使用频次高的药物为甘草、白鲜皮、生地黄、苦参等;外用方剂使用频次高的药物为苦参、黄柏、地肤子、蛇床子、白鲜皮等;高频药物药性以"寒/微寒"为主;药味以"苦、甘"为主;主归"肝、肺、脾"经;湿疹伴瘙痒剧烈者辨证加减使用频次高的药物为地肤子、白鲜皮、乌梢蛇等;通过关联规则发现核心药对为栀子-甘草、黄柏-白鲜皮-苦参、荆芥-防风、蛇床子-地肤子-苦参、白鲜皮-地肤子-苦参。结论中医治疗湿疹处方用药以清热药、解表药、利水渗湿药、攻毒杀虫止痒药为主,甘草、白鲜皮、荆芥、防风和苦参等药物使用频次高。Objective To analyze the prescription regularity of Chinese medicine in treating eczema based on data mining technology. Methods A total of 1 214 literatures on the treatment of eczema with traditional Chinese medicine were searched in the past 20 years from China National Knowledge Internet(CNKI) and Wanfang Academic Journal Full-text Database. Excel software was used to establish a database to analyze the medication frequency and high frequency distribution of drug odor;eczema with severe pruritus syndrome differentiation of medication was analysed;Spss Modeler software was used to explore association rules and prescription rules of eczema medication based on association rules Apriori algorithm, and the rules were visualized through network. Results A total of 584 literatures and 970 prescriptions involving 454 Chinese herbal medicines. Among them, the most frequently used herba of oral decoction were Gancao, Baixianpi, Shengdihuang as well as Kushen and so on;the drugs with high frequency of external prescriptions for external use were Kushen, Huangbai, Difuzi, Shechuangzi, as well as Baixianpi and so on;the drug properties of high-frequency drugs were mainly "cold or slightly cold";the tastes of medicine were mainly bitter and sweet, mainly belonged to the "liver, lung, spleen" meridians;the drugs with high frequency of dialectical addition and subtraction in eczema patients with severe pruritus were Difuzi, Baixianpi as well as Wushaoshe and so on. Association rules showed that the core drug pairs were Zhizi-Gancao, Huangbai-Baixianpi-Kushen, Jingjie-Fangfeng, Shechuangzi-Difuzi-Kushen and Baixianpi-Difuzi-Kushen. Conclusion In the prescription of traditional Chinese medicine for treating eczema, heat clearing drugs, relieving surface drugs, benefiting water infiltration and dampness drugs, attacking toxin, killing insects and relieving itching drugs are the main drugs. The drugs with high frequency of use are Gancao,Baixianpi,Jingjie,Fangfeng as well as Kushen and so on.

关 键 词：湿疹 中医 中药 关联规则 APRIOR算法 白鲜皮 

分 类 号：R275.9[医药卫生—中西医结合] R287[医药卫生—中医皮科]