The TFIID pivot of preinitiation complex  

作　　者：Jingdong Xue Wanli Yang Mengyuan Peng Bing Li 

机构地区：[1]Department of Biochemistry and Molecular Cell Biology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《Science China(Life Sciences)》2021年第12期2214-2217,共4页中国科学（生命科学英文版）

摘　　要：Eukaryotic transcription begins with the assembly of general transcription factors(GTFs)including TFIID,IIA,IIB,IIE,IIF,and IIH,which help Pol II to engage with promoters.The binding of TATA-box binding protein(TBP)to DNA,which causes the bending of TATA sequence,is the first step of the preinitiation complex(PIC)formation,and TBP is essential for almost all gene expression.TBP is an integral part of the TFIID complex which includes 13 other TBP-associated factors(TAFs)and can be separated into 3 submodules(TFIID-A,-B and-C)(Chen et al.,2021a).

关 键 词：EXPRESSION COMPLEX 

分 类 号：Q75[生物学—分子生物学]