SIRT1基因在抑郁症中的作用及机制研究进展  

The role and mechanism of SIRT1 gene in depression

作　　者：国威 肖溪 田裕涛 杨佳佳 GUO Wei;XIAO Xi;TIAN Yu-Tao;YANG Jia-Jia(Institute of Medical Engineering&Translational Medicine,Tianjin University,Tianjin 300072,China;School of Precision Instrument and Opto-Electronics Engineering,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津大学医学工程与转化医学研究院,天津300072 [2]天津大学精密仪器与光电子工程研究院,天津300072

出　　处：《生理学报》2021年第5期828-834,共7页Acta Physiologica Sinica

基　　金：Research from the corresponding author’s laboratory was supported by grants from the National Natural Science Foundation of China(No.81871517);the China Post-doctoral Science Foundation(No.2020M670645)。

摘　　要：抑郁症是一类高致残率且难治愈的精神类疾病,目前其临床诊断和治疗都面临很大的困难,因此研究抑郁症患病机制,寻找抑郁症的潜在治疗靶点,并开发有效临床治疗手段刻不容缓。沉默信息调节因子2同源体1 (silent mating type information regulator 2 homolog 1, SIRT1)作为一种去乙酰化酶,参与细胞衰老、癌症、心血管疾病等多种生物学过程。近年来,越来越多的研究发现SIRT1基因在抑郁症发病过程中发挥了重要的作用,但是其机制尚不明确。本文主要总结了海马、前额叶皮层、杏仁核、下丘脑视交叉上核脑区和伏隔核中SIRT1基因影响抑郁症病理过程的相关研究进展,以期为抑郁症机制研究和抗抑郁药物的研发提供一定的参考和帮助。As a kind of mental illness, depression produces great difficulties in clinical diagnosis and treatment, and has a high disability rate. It is urgent to clarify the mechanism of depression to find potential therapeutic targets and effective clinical treatment methods.As a deacetylase, silent mating type information regulator 2 homolog 1(SIRT1) is involved in many biological processes such as cell aging, cancer, and cardiovascular disease. In recent years, more and more studies have found that SIRT1 gene plays an important role in the pathogenesis of depression, but the mechanism is still unclear. Therefore, this review mainly summarizes the relevant research progress on the role and mechanism of SIRT1 gene in the hippocampus, prefrontal cortex, amygdala, hypothalamic suprachiasmatic nucleus, and nucleus accumbens in depression, in order to provide new ideas for exploring the mechanism and prevention of depression.

关 键 词：SIRT1 抑郁症 海马 前额叶皮层 杏仁核 

分 类 号：R749[医药卫生—神经病学与精神病学] Q189[医药卫生—临床医学]