卒中后认知功能障碍患者外周血miR-96血清IGF-1的相关性及诊断价值  

Correlation and diagnostic value of peripheral blood miR-96 and serum IGF-1 in patients with cognitive dysfunction after stroke

作　　者：吴冠瑾 徐军 黑丹丹 岳亚男 冯静静 李学[2] WU Guanjin;XU Jun;HEI Dandan(Zhengzhou Yihe Hospital,Zhengzhou 450047,China)

机构地区：[1]郑州颐和医院,河南郑州450047 [2]河南省人民医院,河南郑州450003

出　　处：《中风与神经疾病杂志》2021年第10期1083-1085,共3页Journal of Apoplexy and Nervous Diseases

基　　金：2020年度河南省科技攻关计划省部共建重点项目(SBGJ202002005)。

摘　　要：目的探讨卒中后认知功能障碍(PSCI)患者外周血miR-96、血清IGF-1的相关性及诊断价值。方法本院神经内科一、二病区招募的178例缺血性脑卒中恢复期患者,将其分为PSCI组(n=61)、非PSCI组(n=117),并对比外周血miR-96表达水平、血清IGF-1水平的差异。进一步根据中位数将入组患者分为高miR-96组、低miR-96组;高IGF-1组、低IGF-1组各89例并对比MoCA评分值。分析外周血miR-96、血清IGF-1水平对PSCI患者的辅助诊断价值。结果PSCI组患者外周血miR-96表达水平高于非PSCI组,血清IGF-1水平低于非PSCI组(P<0.05)。Pearson检验发现,PSCI患者外周血miR-96表达水平与血清IGF-1水平呈负相关(P<0.05)。高miR-96组、低IGF-1组患者的MoCA评分值分别低于低miR-96组、高IGF-1组患者(P<0.05)。ROC曲线显示,miR-96对PSCI具有较好的诊断价值。结论PSCI患者外周血miR-96高表达可下调IGF-1水平,早期测定其水平对PSCI具有辅助诊断价值。Objective To investigate the correlation and diagnostic value of miR-96 and serum IGF-1 in patients with post-stroke cognitive dysfunction( PSCI). Methods 178 patients with ischemic stroke in recovery stage were recruited and divided into PSCI group( n = 61) and non-PSCI group( n = 117),expression levels of miR-96 and serum IGF-1 were compared. Patients were further divided into high miR-96 group and low miR-96 group according to the median levels,MOCA scores was compared. Auxiliary diagnostic value of miR-96,serum IGF-1 levels in PSCI were analyzed. Results Expression level of miR-96 of PSCI group was higher,serum IGF-1 was lower than that of non-PSCI group( P < 0. 05). Pearson test showed that expression level of miR-96 of PSCI patients was negatively correlated with the level of serum IGF-1( P< 0. 05). MOCA score in high miR-96 group and low IGF-1 group were lower than those in low miR-96 group and high IGF-1 group( P < 0. 05). ROC curve showed mir-96 had good diagnostic value for PSCI. Conclusion High expression of miR-96 in PSCI patients can downregulate the level of IGF-1,and early determination of the level of miR-96 has auxiliary diagnostic value for PSCI.

关 键 词：卒中后认知功能障碍 miR-96 IGF-1 诊断价值 

分 类 号：R743.3[医药卫生—神经病学与精神病学]