Associations between haemodynamics and wall enhancement of intracranial aneurysm  

作　　者：Miaoqi Zhang Fei Peng Xin Tong Xin Feng Yunduo Li Huijun Chen Hao Niu Baorui Zhang Guangrong Song Youxiang Li Peng Liu Aihua Liu Rui Li 

机构地区：[1]Center for Biomedical Imaging Research,Department of Biomedical Engineering,School of Medicine,Tsinghua University,Beijing,China [2]Beijing Neurosurgical Institute,Capital Medical University,Beijing,China [3]Department of Interventional Neuroradiology,Beijing Tiantan Hospital,Beijing,China [4]Department of Neurosurgery,Beijing Hospital,Beijing,China

出　　处：《Stroke & Vascular Neurology》2021年第3期467-475,I0077-I0079,共12页卒中与血管神经病学（英文）

基　　金：supported by the Natural Science Foundation of China(number 81971604);the Natural Science Foundation of China(number 81771233);the Natural Science Foundation of Beijing(number L192013);the Natural Science Foundation of China(number 81901197);Specific Research Projects for Capital Health Development(2018-2-2041);Beijing Science and Technology Planning Project:Beijing-Tianjin-Hebei Collaborative Innovation Promotion Project(Z181100009618035).

摘　　要：Background and purpose Previous studies have reported about inflammation processes(IPs)that play important roles in aneurysm formation and rupture,which could be driven by blood flow.IPs can be identified using aneurysmal wall enhancement(AWE)on high-resolution black-blood MRI(BB-MRI)and blood flow haemodynamics can be demonstrated by four-dimensional-flow MRI(4D-flow MRI).Thus,this study investigated the associations between AWE and haemodynamics in unruptured intracranial aneurysms(IA)by combining 4D-flow MRI and high-resolution BB-MRI.Materials and methods Between April 2014 and October 2017,48 patients with 49 unruptured IA who underwent both 4D-flow MRI and high-resolution BB-MRI were retrospectively included in this study.The haemodynamic parameters demonstrated using 4D-flow MRI were compared between different AWE patterns using the Kruskal-Wallis test and ordinal regression.Results The results of Kruskal-Wallis test showed that the average wall shear stress in the IA(WSSavg-IA),maximum through-plane velocity in the adjacent parent artery,inflow jet patterns and the average vorticity in IA(vorticityavg-IA)were significantly associated with the AWE patterns.Ordinal regression analysis identified WSSavg-IA(p=0.002)and vorticityavg-IA(p=0.033)as independent predictors of AWE patterns.Conclusion A low WSS and low average vorticity were independently associated with a high AWE grade for IAs larger than 4 mm.Therefore,WSS and average vorticity could predict AWE and circumferential AWE.

关 键 词：ANEURYSM INTRACRANIAL HAEMODYNAMICS 

分 类 号：R743[医药卫生—神经病学与精神病学]