Identifying sex-specific differences in the carotid revascularisation literature:findings from a scoping review  

作　　者：Vignan Yogendrakumar Michel Shamy Brian Dewar Dean A Fergusson Dar Dowlatshahi Candyce Hamel Sophia Gocan Mark Fedyk Jean-Louis Mas Peter Rothwell Virginia Howard Olena Bereznyakova On behalf of the WoW-CAD Investigators 

机构地区：[1]Department of Medicine,Division of Neurology and Ottawa Hospital Research Institute,University of Ottawa,Ottawa,Ontario,Canada [2]Epidemiology Program,Ottawa Hospital Research Institute,Ottawa,Ontario,Canada [3]Stroke Prevention Clinic,Ottawa Hospital,Ottawa,Ontario,Canada [4]Bioethics Program,UC Davis Department of Medicine,Sacramento,California,USA [5]Universite Paris Descartes Faculte de Medecine Site Cochin,Paris,lle-de-France,France [6]Service de Neurologie,Hôital Sainte-Anne,Paris,France [7]The University of Alabama at Birmingham School of Medicine,Birmingham,Alabama,USA [8]School of Public Health,University of Alabama at Birmingham,Birmingham,Alabama,USA [9]不详

出　　处：《Stroke & Vascular Neurology》2021年第3期496-499,I0085-I0096,共16页卒中与血管神经病学（英文）

摘　　要：Objective No systematic review of the literature has dedicated itself to looking at the management of symptomatic carotid stenosis in female patients.In this scoping review,we aimed to identify all randomised controlled trials(RCTs)that reported sex-specific outcomes for patients who underwent carotid revascularisation,and determine whether sufficient information is reported within these studies to assess short-term and long-term outcomes in female patients.Design,setting and participants We systematically searched Medline,Embase,Pubmed and Cochrane libraries for RCTs published between 1991 and 2020 that included female patients and compared either endarterectomy with stenting,or any revascularisation(endarterectomy or stenting)with medical therapy in patients with symptomatic high-grade(>50%)carotid stenosis.Results From 1537 references examined,27 eligible studies were identified.Sex-specific outcomes were reported in 13 studies.Baseline patient characteristics of enrolled female patients were reported in 2 of those 13 studies.Common outcomes reported included stroke and death,however,there was significant heterogeneity in the reporting of both periprocedural and long-term outcomes.Sex-specific differences relating to the degree of stenosis and time from index event to treatment are largely limited to studies comparing endarterectomy to medical therapy.Adverse events were not reported by sex.Conclusions Only half of the previously published RCTs and systematic reviews report sex-specific outcomes.Detailed analyses on the results of carotid artery intervention for female patients with symptomatic stenosis are limited.

关 键 词：CAROTID STENOSIS finding 

分 类 号：R743[医药卫生—神经病学与精神病学]