非那西丁的合成与复方阿司匹林的主成分分析——推荐一个有机化学实验  

Synthesis of Phenacetin and Principal Component Analysis of Compound Aspirin:An Organic Chemistry Experiment

作　　者：胡水 赖瑢[1] 李厚金[1] 朱可佳[1] 周磊 邵光[1,2] Shui Hu;Rong Lai;Houjin Li;Kejia Zhu;Lei Zhou;Guang Shao(School of Chemistry,Sun Yat-Sen University,Guangzhou 510275,China;School of Chemistry Engineering and Technology,Sun Yat-Sen University,Zhuhai 519082,Guangdong Province,China)

机构地区：[1]中山大学化学学院,广州510275 [2]中山大学化学工程与技术学院,广东珠海519082

出　　处：《大学化学》2021年第12期127-132,共6页University Chemistry

基　　金：2020年中山大学本科教学质量工程项目(31000-31911100)。

摘　　要：以对氨基苯乙醚为原料,与乙酸成盐提高溶解度与反应活性,再与乙酸酐发生亲核取代反应,两步制备非那西丁。以核磁共振氢谱对化合物结构进行解析,并且利用薄层色谱和高效液相色谱对复方阿司匹林中的有效成分进行分析,讨论了色谱技术之间的区别与联系。本实验内容包括加热回流、离心、重结晶、核磁共振波谱以及薄层色谱和高效液相色谱的应用,有利于培养学生的综合分析问题能力。First,p-phenetidine and acetic acid were used as starting materials,and then acetic anhydride was added through nucleophilic substitution reaction to obtain phenacetin.The structure was identified by ^(1)H-NMR.The components of compound aspirin were analyzed by thin layer chromatography and high performance liquid chromatography,and then the relations and differences between the two chromatography techniques were discussed.This experiment covers the experimental skills such as reflux,centrifugation,recrystallization,NMR,thin layer chromatography and high performance liquid chromatography,and can help the undergraduates improve their analytical abilities.

关 键 词：非那西丁 复方阿司匹林 薄层色谱 高效液相色谱 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]