环状RNAs在前列腺癌中的研究进展  

Research progress of circular RNAs in prostate cancer

作　　者：冯天瑞 严维刚[1] FENG Tian-rui;YAN Wei-gang(Departments of Urology,Peking Union Medical College Hospital,CAMS & PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院泌尿外科,北京100730

出　　处：《基础医学与临床》2022年第1期179-183,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金国家重大科研仪器研制项目(21527801)。

摘　　要：环状RNAs(circRNAs)是一类有着独特的共价闭合环状结构的非编码RNAs,其广泛存在于真核细胞中。近年来的研究表明circRNAs可通过调控microRNAs、与蛋白质结合、调节转录及剪接过程等方式参与包括恶性肿瘤在内的多种疾病的病理生理学过程。circRNAs特殊的结构和复杂的功能使其在肿瘤领域有着巨大的研究潜能。前列腺癌(PCa)是当今全球男性最高发的恶性肿瘤,目前对PCa发生的机制及其诊治方案仍有待进一步深入研究。Circular RNAs(circRNAs)are non-coding RNAs with unique covalently closed circular structures and are widely found in eukaryotic cells.Recent studies have shown that circRNAs are involved in the patho-physiological processes of various diseases including malignant tumors through regulating microRNAs,binding to proteins and regulating transcription and splicing process.The special structure and complex functions of circRNAs make them have great research potential in the field of cancer.Prostate cancer(PCa)is one of the most common malignancies among the world.The the pathogenesis and treatment of PCa still need to be further studied.

关 键 词：环状RNA 前列腺癌 基因调控 

分 类 号：R737.25[医药卫生—肿瘤]