超声造影斑块强化度与前循环脑梗死的相关性研究  

Study on the correlation between plaque enhancement of contrast-enhanced ultrasound and anterior circulation cerebral infarction

作　　者：王华[1] 李伟[1] 苏杭[1] 孙雪[1] 王燕华[1] 秦志平[1] WANG Hua;LI Wei;SU Hang;SUN Xue;WANG Yanhua;QIN Zhiping(The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]郑州大学第二附属医院,河南郑州450003

出　　处：《中国实用神经疾病杂志》2021年第23期2044-2053,共10页Chinese Journal of Practical Nervous Diseases

基　　金：河南省科技攻关项目(编号:182102311215)。

摘　　要：目的通过超声造影(CEUS)研究颈动脉斑块强化度与前循环脑梗死的相关性。方法回顾性分析郑州大学第二附属医院2018-01—2020-01收治的70例颈动脉斑块患者的CEUS资料,其中41例颈动脉狭窄患者纳入斑块组,29例前循环脑梗死患者纳入脑梗组。对比2组患者CEUS参数,不同斑块强化度患者CEUS参数的差异;分析CEUS斑块强化度与患者各项CEUS参数、前循环脑梗死发生的相关性。结果脑梗组斑块厚度、增强强度(EI)、增强密度(ED)、颈动脉狭窄率均高于斑块组(P<0.05),脑梗组造影剂达到时间差(DAT)、造影剂达峰时间差(DTTP)均短于斑块组(P<0.05),2组斑块面积(A)比较差异无统计学意义(P>0.05);不同强化度患者各项斑块CEUS参数差异均有统计学意义(P<0.05),进一步的多重比较亦显示差异有统计学意义(P<0.05);强化度按等级赋值,强化度与斑块厚度、EI、ED、DAT、DTTP及前循环脑梗死的发生均具有相关性(|r|≥0.3,P<0.05)。结论超声造影斑块强化度与前循环脑梗死的发生及各项超声造影参数均具有相关性,可通过超声造影检测斑块强化度为前循环脑梗死的诊断与病情评估提供参考。Objective To investigate the correlation between carotid artery plaque enhancement and anteri⁃or circulation cerebral infarction using contrast-enhanced ultrasound(CEUS).Methods The CEUS data of 70 pa⁃tients with carotid plaque of our hospital from January 2018 to January 2020 were retrospectively analyzed.Among them,41 patients with carotid artery stenosis were included in the plaque group,29 patients with anterior circula⁃tion cerebral infarction were included in the cerebral infarction group.The correlation between plaque enhance⁃ment with CEUS,CEUS parameters and the occurrence of anterior circulation cerebral infarction was analyzed.Re⁃sults The plaque thickness,enhanced intensity(EI),enhanced density(ED)and carotid artery stenosis rates in cerebral infarction group were all higher than those in the plaque group(P<0.05),while difference of arrival time(DAT)and difference of time to peak(DTTP)in cerebral infarction group were both shorter than those in the plaque group(P<0.05).There was no statistically significant difference on plaque area in the two groups(P>0.05).CEUS parameters of all plaques in patients with different intensities were statistically different(P<0.05),and further multiple comparison was also statistically different(P<0.05).The degree of enhancement was rated by grade,and there was a statistical correlation between the degree of enhancement and the occurrence of plaque thickness,EI,ED,DAT,DTTP and anterior circulation cerebral infarction(|r|≥0.3,P<0.05).Conclusion The plaque enhancement of CEUS is correlated with the occurrence of anterior circulation cerebral infarction and various CEUS parameters,which can provide reference for the diagnosis and disease evaluation of anterior circulation cerebral infarction by CEUS.

关 键 词：前循环脑梗死 颈动脉狭窄 超声造影 斑块强化度 相关性分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]