抗NF155抗体阳性的慢性炎性脱髓鞘多发性神经根神经病研究进展  

Research progress of chronic inflammatory demyelinating multiple nerve root neuropathy with anti-NF155 antibody positive

作　　者：陆梦如[1] 钊岩 梁军利[1] 李何鹏[1] 梁津瑜 梅育嘉[1] 陈海[3] LU Mengru;ZHAO Yan;LIANG Junli;LI Hupeng;LIANG Jinyu;MEI Yujia;CHEN Hai(The Second Affiliated Hospital,Guangxi Medical University,Nanning 530027,China;The Third Hospital of Ji’nan,Ji’nan 250132,China;Xuanwu Hospital of Capital Medical University,Beijing 100053,China)

机构地区：[1]广西医科大学第二附属医院,广西南宁530027 [2]济南市第三人民医院,山东济南250132 [3]首都医科大学宣武医院,北京100053

出　　处：《中国实用神经疾病杂志》2021年第23期2108-2116,共9页Chinese Journal of Practical Nervous Diseases

摘　　要：慢性炎性脱髓鞘多发性神经根神经病(CIDP)是一种免疫介导的周围神经系统脱髓鞘疾病,近年来,抗郎飞结区或结旁区抗体阳性的CIDP逐渐被认识。包括抗NF155、NF186、CNTN1、Caspr1抗体,每种自身抗体对应亚型的临床特征、对治疗的反应都有显著的差异。抗NF155 IgG4抗体阳性的CIDP患者发病年龄较轻,出现足下垂、步态障碍、震颤的频率较高,且对IVIg治疗反应差。相应抗体的检测可以作为一种生物标志物,为CIDP诊断提供了新思路。本文对抗NF155抗体阳性的慢性炎性脱髓鞘多发性神经根神经病发病机制、临床特点、神经电生理、治疗进展等进行综述。Chronic inflammatory demyelinating multiple nerve root neuropathy(CIDP)is an immune-me⁃diated demyelinating diseases of the peripheral nervous systerm.In recent years,it has been gradually recog⁃nized that CIDP is positive for anti-ranfly-node or paragonal-region antibodies.Anti-NF155,NF186,CNTN1 and CASPR1 antibodies were included.The clinical characteristics and response to treatment of the corre⁃sponding subtypes of each autoantibody were significantly different.Patients with anti-NF155 IgG4 positive CIDP had a younger age of onset,higher frequency of foot drop,gait disorder,tremor,and poor response to IVIg treatment.The detection of corresponding antibodies can be used as a biomarker,which provides a new idea for the diagnosis of CIDP.In this review,we reviewed the pathogenesis,clinical characteristics,neuroelec⁃trophysiology and treatment progress of anti-NF155 antibody positive chronic inflammatory demyelinating mul⁃tiple nerve root neuropathy.

关 键 词：慢性炎性脱髓鞘多发性神经根神经病 抗NF155抗体阳性 发病机制 临床特点 

分 类 号：R744[医药卫生—神经病学与精神病学]