肿瘤免疫治疗研究进展  

Advances in research on tumor immunotherapy

作　　者：李龙 谢成英 郑明月 蒋华良[1,2] LI Long;XIE Chengying;ZHENG Mingyue;JIANG Hualiang(Shanghai Institute for Advanced Immunochemical Studies,ShanghaiTech University,Shanghai 201210,China;Drug Discovery&Development Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China)

机构地区：[1]上海科技大学免疫化学研究所,上海201210 [2]中国科学院上海药物研究所药物发现与设计中心,上海201203 [3]中国科学院分子细胞科学卓越创新中心,上海200031

出　　处：《自然杂志》2021年第6期391-399,共9页Chinese Journal of Nature

摘　　要：肿瘤免疫治疗通过激发或重建机体的免疫系统,从而控制和杀伤肿瘤细胞,是继手术、放疗、化疗、靶向治疗后的另一种有效的肿瘤治疗手段。免疫学和肿瘤生物学等多个学科的快速发展促使各种新兴的肿瘤免疫疗法进入临床研究并展现出强大的治疗潜力。目前临床常见的肿瘤免疫疗法包括单克隆抗体疗法、免疫检查点阻断剂疗法、过继细胞疗法、溶瘤病毒疗法和肿瘤疫苗等。文章回顾肿瘤免疫疗法的发展历程,分析最新的研究进展,并对未来进行展望,以期为肿瘤免疫治疗药物的研发提供参考。Tumor immunotherapy can control and kill tumor cells by stimulating or restoring the immune system.It is another effective treatment after surgery,radiotherapy,chemotherapy and targeted therapy.A variety of emerging tumor immunotherapies are being applied in clinical research and demonstrate the potential of powerful treatment,benefiting from the rapid development of multiple-subjects such as immunology and tumor biology.At present,clinical immunotherapeutic strategies for cancer include therapeutic monoclonal antibody immunotherapy,immune checkpoint inhibitor therapy,adoptive cell therapy,oncolytic virus therapy,and tumor vaccine.This paper reviews the development of tumor immunotherapy,and analyzes the latest research progress and future prospects,in order to provide reference for drug research and development in tumor immunotherapy.

关 键 词：肿瘤 肿瘤免疫 免疫治疗 肿瘤微环境 

分 类 号：R730.51[医药卫生—肿瘤]