葡萄糖6磷酸脱氢酶在恶性肿瘤中的研究进展  

Research progress of glucose 6 phosphorus dehydrogenase in malignant tumor

作　　者：马月 范方田[1] MA Yue;FAN Fangtian(Bengbu Medical College,Bengbu 233030,Anhui,China)

机构地区：[1]蚌埠医学院,安徽蚌埠233030

出　　处：《中国临床药理学与治疗学》2021年第12期1430-1436,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：蚌埠医学院重大科技培育项目(2020byfy001);国家自然基金面上项目(81973658);中国博士后基金(一等资助)(2018M640529)。

摘　　要：葡萄糖-6-磷酸脱氢酶(glucose-6-phosphate dehydrogenase,G6PD)是磷酸戊糖途径(PPP)的限速酶,主要维持还原等效烟酰胺腺嘌呤二核苷酸磷酸(NADPH)以及细胞内氧化还原反应平衡。减弱G6PD活性或PPP功能失调可阻止正常细胞增殖,严重缺乏G6PD会损害胚胎发育,延缓器官生长。现许多研究已证明,G6PD的异常激活会导致多种类型癌症的细胞增殖和适应能力增强,并易引起治疗药物耐药,加大临床治疗困难。研究G6PD在癌细胞中的作用机制,找出新的潜在药物治疗靶点已经成为临床治疗的迫切需要。Glucose-6-phosphate dehydrogenase(Glucose-6-phosphate dehydrogenase,G6 PD)is the rate-limiting enzyme of pentose phosphate pathway(PPP),which mainly maintains the balance of NADPH and intracellular redox reaction.Reducing G6 PD activity or PPP dysfunction can prevent normal cell proliferation,and severe lack of G6 PD can damage embryonic development and delay organ growth.At present,many studies have proved that abnormal activation of G6 PD can lead to the enhancement of cell proliferation and adaptability of various types of cancer,and it is easy to cause drug resistance and increase the difficulty of clinical treatment.It has become an urgent need for clinical treatment to study the mechanism of G6 PD in cancer cells and identify new potential drug therapeutic targets.

关 键 词：葡萄糖-6-磷酸脱氢酶 氧化还原 癌症 细胞死亡 葡萄糖-6-磷酸脱氢酶抑制剂 

分 类 号：R73[医药卫生—肿瘤]