以苦参碱类生物碱为前体的D环抗肿瘤活性结构改造  

Structural Modification of D-ring Antitumor Activity Employing Matrine Alkaloids as Precusors

作　　者：赵俊 蔡小华[1] ZHAO Jun;CAI Xiao-hua(School of Chemical Engineering,Guizhou Minzu University,Guiyang 550025,China)

机构地区：[1]贵州民族大学化学工程学院,贵州贵阳550025

出　　处：《化学试剂》2022年第1期136-141,共6页Chemical Reagents

基　　金：贵州省科技计划项目([2018]1077)。

摘　　要：苦参碱是从苦参、苦豆子等植物中分离得到的一类喹诺里西啶类生物碱,具有抗肿瘤、抗病毒、神经保护、杀虫等多种生物活性。苦参碱系列生物碱是一种极好的结构改造的前体,引起广大学者的浓厚兴趣。近年来,许多基于苦参碱为原料的衍生物被设计并合成出来,取得了较好的研究结果。通过对研究苦参碱及其衍生物抗肿瘤作用的文献进行分析和整理,从苦参碱的C-13、C-14、C-15羰基、D环的开环、形成离子配合物和拼合物的结构改造方面综述了其相关的研究进展。Matrine is a kind of quinolizidine alkaloids isolated from Sophoraflavescens and Sophoraalopecuroides,and shows many biological activities such as antitumor,antiviral,neuroprotective,insecticidal and so on.Matrine-type alkaloids are excellent precursors for the synthesis and modification,which have aroused great interest of scholars.In recent years,many derivatives based on matrine-type alkaloids have been designed and synthesized,and good results have been achieved.In this paper,the anti-tumor effects of matrine and its derivatives were analyzed and sorted out,and the related research progress was summarized from the structural modification of C-13,C-14,C-15 carbonyl,ring opening of D-ring,formation of ionic complexes and complexes of matrine.

关 键 词：苦参碱 生物碱 前体 结构改造 抗肿瘤 

分 类 号：R914.5[医药卫生—药物化学]