熄风清火活血化痰汤对急性缺血性中风(风火痰瘀证)患者血清IL-1β、IL-5、IL-17、TNF-α水平的影响  

Efficacy of Xifeng Qinghuo Huoxue Huatan Decoction in Treating Acute Phase of Ischemic Stroke with Syndrome of Endogenous-Wind,Fire,Phlegm and Blood Stasis and Its Effects on serum IL-1β,IL-5,IL-17,TNF-α

作　　者：苏钰 朱文浩[2] 刘宝殊[2] 郭睿 陈香岩 王泰勇[2] 胡浩[2] Su Yu;Zhu Wenhao;Liu Baoshu;Guo Rui;Chen Xiangyan;Wang Taiyong;Hu Hao(Shandong University of Traditional Chinese Medicine,Shandong,Jinan 210000,China)

机构地区：[1]山东中医药大学,山东济南210000 [2]山东省淄博市中医医院,山东淄博255000

出　　处：《中国中医急症》2021年第12期2166-2169,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：淄博市科学技术发展计划项目(2017kj010074);淄博市重点研发计划项目(2019ZC010124);山东省中医药高层次人才培育项目专项经费资助。

摘　　要：目的观察熄风清火活血化痰汤治疗急性缺血性中风(风火痰瘀证)的临床疗效及对血清白细胞介素-1β(IL-1β)、白细胞介素-5(IL-5)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)水平的影响。方法将60例急性缺血性中风(风火痰瘀证)患者随机分为对照组和治疗组。两组患者均接受西医常规治疗,治疗组加用熄风清火活血化痰汤,两组疗程均为10 d。比较两组治疗前后临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)评分、改良rankin量表(mRS)评分及血清IL-1β、IL-5、IL-17、TNF-α水平。10名健康受试者作为正常组,检测其血清IL-1β、IL-5、IL-17、TNF-α水平。结果治疗组临床总有效率高于对照组(P<0.05)。治疗组神经功能评分治疗后均有改善(P<0.01),且NIHSS评分、mRS评分差值大于对照组(P<0.01)。治疗组治疗后血清IL-1β、IL-17A、TNF-α水平低于治疗前(P<0.01),与对照组同期比较血清IL-17A、TNF-α水平有统计学意义(P<0.05)。结论熄风清火活血化痰汤能提高急性缺血性中风(风火痰瘀证)患者的临床疗效,可能与降低患者的血清IL-17A、TNF-α水平,进而保护脑组织免受损害有关。Objective:To observe the efficacy of Xifeng Qinghuo Huoxue Huatan Decoction in treating acute phase of ischemic stroke with syndrome of endogenous-wind,fire,phlegm and blood stasis and its effects on serum IL-1β,IL-5,IL-17,TNF-α.Methods:A total of 60 acute ischemic stroke patients with syndrome of endogenouswind,fire,phlegm and blood stasis were randomly divided into treatment group and control group.The control group was given standard western medicine treatment,and the treatment group received standard western medicine treatment and Xifeng Qinghuo Huoxue Huatan Decoction.After 10 days of treatment,the clinical efficacy,NIH stroke scale,modified Rankin scale,Barthel index scale,and the serum levels of IL-1β,IL-5,IL-17,TNF-αwere evaluated.Another 10 healthy subjects were selected as the normal group to detect the serum levels of IL-1β,IL-5,IL-17 and TNF-α.Results:The total clinical effective rate of the treatment group was higher than that of the control group(P<0.05).The efficacy indicators of the treatment group were improved after treatment(P<0.01),and the difference between NIHSS score and m RS score was greater than that of the control group(P<0.01).Serum levels of IL-1β,IL-17 A,and TNF-αafter treatment in the treatment group were lower than before treatment(P<0.01),and the serun IL-17 A and TNF-αlevels were statistically significant compared with the control group(P<0.01).Conclusion:Xifeng Qinghuo Huoxue Huatan Decoction can improve clinical efficacy of treating acute phase of ischemic stroke with syndrome of endogenous-wind,fire,phlegm and blood stasis,which may be related to the reduction of serum IL-17 and TNF-αlevels and thereby protecting brain tissue from damage.

关 键 词：急性缺血性中风 风火痰瘀证 白细胞介素-1β 白细胞介素-5 白细胞介素-17 肿瘤坏死因子-α 

分 类 号：R7439[医药卫生—神经病学与精神病学]