辅助性T细胞17/调节性T细胞平衡与缺血性卒中  

T Helper cell 17/regulatory T cell balance and ischemic stroke

作　　者：曹孟欣 韦紫君 张云云[1] Mengxin Cao;Zijun Wei;Yunyun Zhang(Department of Neurology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院神经内科,200437

出　　处：《国际脑血管病杂志》2021年第10期781-784,共4页International Journal of Cerebrovascular Diseases

基　　金：上海市科学技术委员会中医引导项目(19401934900);上海中医药大学附属岳阳中西医结合医院重点项目(2019YYZ09)。

摘　　要：炎症免疫反应贯穿缺血性卒中病程的始终。不同亚群CD4+T细胞在缺血性卒中病程中起着复杂而重要的作用。其中,辅助性T细胞17(T helper cell 17,Th17)与调节性T细胞(regulatory T cell,Treg)的促炎与抑炎作用的平衡与卒中转归密切相关。文章就Th17/Treg平衡在缺血性卒中中的作用进行了综述,旨在加深对缺血性卒中后免疫炎症机制的认识,同时探究缺血性卒中病程中可能的治疗靶点。Inflammatory immune response runs through the course of ischemic stroke.Different subgroups of CD4+T cells play a complex and important role in the course of ischemic stroke.Among them,the balance of pro-inflammatory effect of T helper cell 17(Th17)and anti-inflammatory effect of regulatory T cells(Treg)is closely associated with the outcome of stroke.This article reviews the role of Th17/Treg balance in ischemic stroke,in order to deepen the understanding of the mechanism of immune inflammation after ischemic stroke and explore possible therapeutic targets in the course of ischemic stroke.

关 键 词：卒中 脑缺血 TH17细胞 T-淋巴细胞 调控 

分 类 号：R743.3[医药卫生—神经病学与精神病学]