Th17细胞及其相关细胞因子在IBD中研究新进展  

New progress in research of Th17 cells and related cytokines in inflammatory bowel disease

作　　者：袁余懿 刘与进 范恒[1] Yu-Yi Yuan;Yu-Jin Liu;Heng Fan(Department of Integrated Traditional Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China)

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合科,湖北武汉430022

出　　处：《世界华人消化杂志》2021年第24期1402-1409,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金,No.81774093;湖北省重点研发项目,No.2020BCB001.

摘　　要：炎症性肠病(inflammatory bowel disease,IBD)是一种慢性非特异性肠道炎症疾病,是一种免疫性疾病,目前尚无根治疗法,肠道免疫是炎症性肠病的研究重点,本文就Th17细胞及其相关细胞因子在炎症性肠病中的新研究进行综述,包括炎症性肠病病因、与适应性免疫的关系、与Th17细胞的关系,Th17细胞介绍、其相关细胞因子的介绍,和它们在IBD的研究状况,最后展望Th17细胞与IBD的未来研究方向.Inflammatory bowel disease(IBD)is a chronic non-specific intestinal inflammatory disease.IBD is an immune disease,and there is no cure for it at present.Intestinal immunity is the research focus of IBD.Focusing on Th17 cells and related cytokines,this article reviews the updated research on IBD,including its etiology,its relationship with adaptive immunity,and its relationship with Th17 cells.We also introduce Th17 cells and related cytokines,and their research in IBD.Finally,we point out the future research direction of Th17 cells in IBD.

关 键 词：炎症性肠病 TH17细胞 肠道免疫 IL-17 IL-23 IL-10 IL-22 

分 类 号：R574[医药卫生—消化系统]