Increased tensin 4 expression is related to the histological type of gastric cancer  

作　　者：Marcin Nizioł Justyna Zińczuk Konrad Zaręba Katarzyna Guzińska-Ustymowicz Anna Pryczynicz 

机构地区：[1]Department of General Pathomorphology,Medical University of Bialystok,Białystok 15-089,Poland [2]Department of Clinical Laboratory Diagnostics,Medical University of Białystok,Bialystok 15-089,Poland [3]The Second Clinical Department of General and Gastroenterological Surgery,Medical University of Bialystok,Białystok 15-089,Poland

出　　处：《World Journal of Clinical Oncology》2021年第12期1202-1214,共13页世界临床肿瘤学杂志（英文版）

摘　　要：BACKGROUND Gastric cancer(GC)is one of the most common malignant tumors worldwide.Tensin 4(TNS4)is an adhesive protein belonging to the tensin family.This protein is located in focal adhesion sites.The TNS4 gene is considered an oncogene in numerous cancers.This protein plays an important role in adhesion,migration and proliferation of cells.AIM To evaluate expression of TNS4 protein in GC tissues and analysis of the clinical and histopathological parameters as well as the overall survival rate of patients.METHODS The expression of TNS4 was assessed in 89 patients using immunohistochemistry.RESULTS Positive expression of TNS4 was observed in 49 of 89 patients(55.06%).Higher TNS4 expression was more common in GC tumors with a diameter≥5 cm(P=0.040).We demonstrated that an increase in TNS4 expression was more frequent in tumors of the histological type without mucinous components than in tumors from mucosal cancers(P=0.023).Furthermore,TNS4 expression was higher in moderately differentiated tumors than in poorly differentiated and non-differentiated tumors(P=0.002).Increased TNS4 expression was also noted in the intestinal type of GC according to Lauren’s classification(P=0.020).No statistically significant correlation was found between the expression of TNS4 and the overall survival rate of patients.CONCLUSION TNS4 expression was significantly higher in tumors with a diameter≥5 cm of the moderately differentiated intestinal type(according to Lauren’s classification)of GC without a mucinous component.Therefore,increased TNS4 expression is related to the histological type of GC with a better prognosis.

关 键 词：Gastric cancer Tensin 4 Adhesion proteins IMMUNOHISTOCHEMISTRY 

分 类 号：R73[医药卫生—肿瘤]