Preclinical safety,effectiveness evaluation,and screening of functional bacteria for fecal microbiota transplantation based on germ-free animals  

作　　者：Ya-Peng Yang Xue-Ying Zhang Bo-Ta Cui Hang Zhang Zhi-Feng Wu Xiang Tan Wei Cheng Xi Zhu Fa-Ming Zhang Huan-Long Qin Hong Wei 

机构地区：[1]State Key Laboratory of Agricultural Microbiology,College of Animal Sciences and Technology,Huazhong Agricultural University,Wuhan 430070,Hubei Province,China [2]Intestinal Microenvironment Treatment Center,Tenth People’s Hospital of Tongji University,Shanghai 200072,China [3]Medical Center for Digestive Diseases,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,Jiangsu Province,China [4]Key Lab of Holistic Integrative Enterology,Nanjing Medical University,Nanjing 210011,Jiangsu Province,China [5]Division of Microbiotherapy,Sir Run Run Shaw Hospital,Nanjing Medical University,Nanjing 211166,Jiangsu Province,China [6]Central Laboratory,Clinical Medicine Scientific and Technical Innovation Park,Shanghai Tenth People's Hospital,Tongji University,Shanghai 200435,China

出　　处：《World Journal of Meta-Analysis》2021年第6期496-504,共9页世界荟萃分析杂志

摘　　要：Fecal microbiota transplantation(FMT),also known as fecal bacterial therapy,is a treatment option that can quickly reconstruct the normal composition of intestinal microbes,and it has a good therapeutic effect on Clostridium difficile infection,as well as on other microecological disorders.However,the causal mechanism of FMT efficacy remains to be clarified,its safety is a major problem,and the standardization and acceptability of FMT need to be improved.This review summarizes its current research status and potential research areas that need to be strengthened,and proposes to clarify the safety of FMT and the causal relationship between FMT and therapeutic effectiveness based on germ-free animals.Meanwhile,the research system is combined with multiomics technology to screen the effective bacteria in FMT,and develop standard,safe,effective and controllable flora of FMT.

关 键 词：Fecal microbiota transplantation EFFECTIVENESS Safety Germ-fee animals Functional bacteria 

分 类 号：R57[医药卫生—消化系统]