Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice  

作　　者：Hui Xia Xiangling Shi Beijia Zhou Jing Sui Chao Yang Hechun Liu Ligang Yang Shaokang Wang Guiju Sun 

机构地区：[1]Key Laboratory of Environmental Medicine and Engineering of Ministry of Education,and Department of Nutrition and Food Hygiene,School of Public Health,Southeast University,Nanjing 210009,China [2]Research Institute for Environment and Health,School of Law and Public Affairs,Nanjing University of Information Science and Technology,Nanjing,Jiangsu,210044,China

出　　处：《Food Science and Human Wellness》2022年第1期32-40,共9页食品科学与人类健康（英文）

基　　金：the support from National Key Research and Development Program of China(NO.2016YFD400604-02);the National Natural Science Foundation of China(NO.82003457);Jiangsu Province Science Foundation for Youths(NO.BK20200366);the Fundamental Research Funds for the Central Universities and“Zhishan”Scholars Programs of Southeast University.

摘　　要：Flaxseed has displayed the potential beneficial as functional foods.However,most studies focused on effects of flaxseed extracts or ingredients in flaxseed.Besides,few studies showed that flaxseed extracts contributed to anti-type 1 diabetes(T1D),yet the underlying mechanism is still unknown.In the present study,16.7% of milled flaxseed(MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks.The results showed that MF feeding 1)slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test,2)decreased liver tumor necrosis factor-αlevels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways,3)and significantly altered some beneficial bacteria in gut microbiota.In conclusion,the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice.

关 键 词：Milled flaxseed Type 1 diabetes Gut microbiota TLR4/NF-κB pathway 

分 类 号：TS201.4[轻工技术与工程—食品科学]